Discipline of Paediatrics, University of Adelaide, Adelaide, South Australia, Australia.
Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Arch Dis Child. 2018 Mar;103(3):235-239. doi: 10.1136/archdischild-2017-312968. Epub 2017 Aug 9.
While ovulation is most likely to occur in adolescent girls with regular menstrual cycles, there are limited data on the incidence of ovulation in girls with irregular menstrual cycles in early postmenarcheal years. The aim of the study was to evaluate the presence of ovulation in healthy postmenarcheal girls with irregular menstrual cycles.
METHODS, DESIGN AND SUBJECTS: Prospective cohort study over 12 weeks including 40 healthy postmenarcheal girls recruited from the population-based cohort of adolescents from Western Australian Pregnancy Cohort (Raine) Study with irregular menstrual cycles defined by either menstrual cycles <21 days or >35 days in duration or cycle length that varied from month to month by >4 days according to menstrual diaries.
Ovulation defined by urinary pregnanediol-3α-glucuronide/creatinine measurements higher than three times above minimum value obtained from 12 samples (1 per week).
Forty girls (37 Caucasians) with irregular menstrual cycles aged 15.1 (median (IQR) 14.9-15.4) years who were 2.3 (1.9-3.3) years postmenarche were assessed. Urinary pregnanediol-3α-glucuronide/creatinine values identified that 33 girls (82.5%) ovulated during the 3 months of observation and 7 girls had anovulatory cycles. Menstrual diaries collected for a median (IQR) of 159 (137.5-188.2) days showed median minimal and maximum menstrual cycle duration of 24 (11.5-29) and 38.5 (35-48) days, respectively.
A large proportion of healthy adolescent girls with irregular menstrual cycles are still ovulating despite irregular and infrequent menses.
虽然排卵最有可能发生在月经周期规律的青春期女孩中，但关于初潮后早期月经周期不规律的女孩排卵发生率的数据有限。本研究旨在评估月经初潮后月经周期不规律的健康女孩是否存在排卵。
方法、设计和受试者：这是一项为期 12 周的前瞻性队列研究，共纳入 40 名来自西澳大利亚妊娠队列（Raine）研究的青春期人群中月经周期不规律的健康初潮后女孩，月经周期不规律的定义为月经周期持续时间<21 天或>35 天，或根据月经日记，每个月的周期长度变化>4 天。
通过尿液孕二醇-3α-葡糖苷酸/肌酐测量值高于从 12 个样本（每周 1 个）中获得的最小值的 3 倍以上来定义排卵。
评估了 40 名（37 名白人）月经周期不规律的女孩，年龄为 15.1 岁（中位数（IQR）14.9-15.4 岁），初潮后 2.3 岁（1.9-3.3 岁）。尿液孕二醇-3α-葡糖苷酸/肌酐值表明，在 3 个月的观察期间，33 名女孩（82.5%）排卵，7 名女孩无排卵周期。收集了中位数（IQR）为 159（137.5-188.2）天的月经日记，显示最小和最大月经周期持续时间中位数分别为 24（11.5-29）和 38.5（35-48）天。
尽管月经不规律且不频繁，但大多数月经周期不规律的健康青春期女孩仍在排卵。
