使用生长抑素类似物（SMS 201-995）治疗餐后低血压。

Treatment of postprandial hypotension with a somatostatin analogue (SMS 201-995).

作者信息

Hoeldtke R D, Boden G, O'Dorisio T M

出版信息

Am J Med. 1986 Dec 22;81(6B):83-7. doi: 10.1016/0002-9343(86)90588-7.

Abstract

A somatostatin analogue, compound SMS 201-995, was used to treat postprandial hypotension in a patient with autonomic neuropathy. Prior to treatment, the patient's mean blood pressure decreased 50 to 80 mm Hg after each meal, resulting in frequent loss of consciousness. Subcutaneous administration of low doses of compound SMS 201-995 (12 to 16 micrograms) prevented the postprandial hypotension. The therapeutic benefits of SMS 201-995 dissipated after a few hours, however, which made it necessary to administer the drug with each meal. No adverse effects of this agent were noted over a nine-month treatment period. Compound SMS 201-995 provided safe and effective therapy for postprandial hypotension.

摘要

一种生长抑素类似物，即化合物SMS 201-995，被用于治疗一名患有自主神经病变患者的餐后低血压。治疗前，该患者每餐饭后平均血压下降50至80毫米汞柱，导致频繁意识丧失。皮下注射低剂量的化合物SMS 201-995（12至16微克）可预防餐后低血压。然而，SMS 201-995的治疗效果在数小时后就消失了，这使得每餐都必须给药。在九个月的治疗期内未观察到该药物的不良反应。化合物SMS 201-995为餐后低血压提供了安全有效的治疗方法。