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普瑞巴林和加巴喷丁对腹腔镜胆囊切除术后疼痛及阿片类药物用量的影响。

Effects of pregabalin and gabapentin on postoperative pain and opioid consumption after laparoscopic cholecystectomy.

作者信息

Eidy Mohammad, Fazel Mohammad Reza, Abdolrahimzadeh Hossein, Moravveji Ali Reza, Kochaki Ebrahim, Mohammadzadeh Mahdi

机构信息

Trauma Research Center, Kashan University of Medical Sciences, Kashan, Iran.

Shahid Beheshti Hospital, Kashan University of Medical Sciences, Kashan, Iran.

出版信息

Korean J Anesthesiol. 2017 Aug;70(4):434-438. doi: 10.4097/kjae.2017.70.4.434. Epub 2017 Feb 21.

DOI:10.4097/kjae.2017.70.4.434
PMID:28794839
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5548946/
Abstract

BACKGROUND

Gabapentin and pregabalin are antiepileptic drugs that are also used for chronic pain treatment. This study evaluated the effects of pregabalin and gabapentin on postoperative pain in patients undergoing laparoscopic cholecystectomy.

METHODS

A total of 108 candidates for elective laparoscopic cholecystectomy were randomly assigned to gabapentin (n = 36), pregabalin (n = 36), and placebo (n = 36) groups. Patients received 800 mg of gabapentin or 150 mg of pregabalin orally one hour before surgery. Postoperative analgesia was administered by pethidine via patient-controlled analgesia. The amount of opioid consumed, number of nausea events, vomiting, and pain scores at 2, 6, 12, and 24 hours after surgery were recorded.

RESULTS

The gabapentin and pregabalin groups had significantly lower pain intensity than the placebo group, and pain intensity in the pregabalin group decreased more compared to the gabapentin group. The mean amount of pethidine consumption in the placebo group was significantly higher than in the gabapentin and pregabalin groups.

CONCLUSIONS

A single dose of gabapentin or pregabalin decreased postoperative pain and nausea, as well as vomiting and opioid consumption after laparoscopic cholecystectomy. Moreover, the findings revealed that pregabalin was superior to gabapentin for reducing postoperative pain.

摘要

背景

加巴喷丁和普瑞巴林是抗癫痫药物，也用于慢性疼痛治疗。本研究评估了普瑞巴林和加巴喷丁对接受腹腔镜胆囊切除术患者术后疼痛的影响。

方法

总共108名择期腹腔镜胆囊切除术的候选患者被随机分配到加巴喷丁组（n = 36）、普瑞巴林组（n = 36）和安慰剂组（n = 36）。患者在手术前1小时口服800毫克加巴喷丁或150毫克普瑞巴林。术后通过患者自控镇痛给予哌替啶进行镇痛。记录术后2、6、12和24小时的阿片类药物消耗量、恶心事件数量、呕吐情况和疼痛评分。

结果

加巴喷丁组和普瑞巴林组的疼痛强度明显低于安慰剂组，且普瑞巴林组的疼痛强度相比加巴喷丁组下降得更多。安慰剂组哌替啶的平均消耗量明显高于加巴喷丁组和普瑞巴林组。

结论

单剂量加巴喷丁或普瑞巴林可减轻腹腔镜胆囊切除术后的疼痛、恶心、呕吐，并减少阿片类药物的消耗量。此外，研究结果显示普瑞巴林在减轻术后疼痛方面优于加巴喷丁。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/651f/5548946/878caf54ac92/kjae-70-434-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/651f/5548946/878caf54ac92/kjae-70-434-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/651f/5548946/878caf54ac92/kjae-70-434-g001.jpg

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