关于3 - O - 甲基 - D - 葡萄糖对葡萄糖转运蛋白4（GLUT4）活性调节的支持性数据。

Supportive data on the regulation of GLUT4 activity by 3-O-methyl-D-glucose.

作者信息

Shamni Ofer, Cohen Guy, Gruzman Arie, Zaid Hilal, Klip Amira, Cerasi Erol, Sasson Shlomo

机构信息

The Institute for Drug Research, Section of Pharmacology, Diabetes Research Unit, Faculty of Medicine, The Hebrew University, Jerusalem 9112102, Israel.

Program in Cell Biology, Hospital for Sick Children, Toronto, OT, Canada M5G 1XB.

出版信息

Data Brief. 2017 Jul 28;14:329-336. doi: 10.1016/j.dib.2017.07.069. eCollection 2017 Oct.

DOI:10.1016/j.dib.2017.07.069

PMID:28795110

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5547241/

Abstract

The data presented in this article are related to the research article entitled "Regulation of GLUT4 activity in myotubes by 3-O-methyl-D-glucose" (Shamni et al., 2017) [1]. These data show that the experimental procedures used to analyze the effects of 3-O-methyl-D-glucose (MeGlc) on the rate of hexose transport into myotubes were valid and controlled. The stimulatory effect of MeGlc was limited to glucose transporter 4 (GLUT4) and was independent of ambient glucose and protein synthesis. Cornish-Bowden kinetic analysis of uptake data revealed that MeGlc attenuated indinavir-induced inhibition of hexose transport in a competitive manner.

摘要

本文所呈现的数据与题为《3 - O - 甲基 - D - 葡萄糖对肌管中GLUT4活性的调节》（沙姆尼等人，2017年）[1]的研究论文相关。这些数据表明，用于分析3 - O - 甲基 - D - 葡萄糖（MeGlc）对己糖转运进入肌管速率影响的实验程序是有效的且得到了控制。MeGlc的刺激作用仅限于葡萄糖转运蛋白4（GLUT4），且与环境葡萄糖和蛋白质合成无关。对摄取数据进行的康沃尔 - 鲍登动力学分析表明，MeGlc以竞争性方式减弱了茚地那韦诱导的己糖转运抑制作用。