Podosinovikova N P, Matveev V I, Alisova N P, Dolgo-Saburov V B
Biull Eksp Biol Med. 1987 Jan;103(1):71-3.
The accumulation of tyrosine-aminotransferase (TAT) as a marker of the individual gene activation was studied in the rat tissue after the administration of cholinomimetics and cholinolytics in order to elucidate the relations between cholinoreceptor functional state and the genetic apparatus. The regulation of TAT synthesis was found to be controlled by both cholinomimetic concentration and the density of cholinoreceptors in hepatocytes. Transsynaptic regulation of TAT activity was shown to be different in the brain and liver. It is suggested that the approaches discussed might be useful for the analysis of the relationship between cholinoreceptor state and the regulation of biochemical functions of target cells.
为了阐明胆碱能受体功能状态与遗传机制之间的关系，研究了在大鼠组织中给予拟胆碱药和抗胆碱药后，作为个体基因激活标志物的酪氨酸转氨酶（TAT）的积累情况。发现TAT合成的调节受拟胆碱药浓度和肝细胞中胆碱能受体密度的控制。TAT活性的跨突触调节在脑和肝中表现不同。有人认为，所讨论的方法可能有助于分析胆碱能受体状态与靶细胞生化功能调节之间的关系。
