State Key Laboratory of Physical Chemistry of Solid Surfaces & Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University , Xiamen 361005, China.
School of Chemistry and Chemical Engineering, Jiangsu University , Zhenjiang 212013, China.
J Org Chem. 2017 Sep 1;82(17):9119-9125. doi: 10.1021/acs.joc.7b01689. Epub 2017 Aug 21.
A concise and flexible synthesis of α,β-unsaturated amidines via gold-catalyzed intermolecular ynamide amination/carbene 1,2-shift between ynamides and benzylic azides has been developed. Under mild reaction conditions, various α,β-unsaturated amidines were obtained in mostly good yields, thus providing an efficient and atom-economic way for the construction of valuable α,β-unsaturated amidines.
通过金催化的炔酰胺分子间亚胺酰胺氮丙啶/卡宾 1,2-迁移反应,实现了α,β-不饱和脒的简洁、灵活合成。在温和的反应条件下,主要以良好的收率得到了各种α,β-不饱和脒,为构建有价值的α,β-不饱和脒提供了一种高效、原子经济性的方法。