†State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
‡State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
J Am Chem Soc. 2015 Aug 5;137(30):9567-70. doi: 10.1021/jacs.5b06015. Epub 2015 Jul 28.
The generation of α-imino gold carbenes via gold-catalyzed intermolecular reaction of azides and ynamides is disclosed. This new methodology allows for highly regioselective access to valuable 2-aminoindoles and 3-amino-β-carbolines in generally good to excellent yields. A mechanistic rationale for this tandem reaction, especially for the observed high regioselectivity, is supported by DFT calculations.
本文公开了通过金催化的叠氮化物和炔酰胺的分子间反应生成α-亚氨基金卡宾的方法。这种新方法可以高区域选择性地获得有价值的 2-氨基吲哚和 3-氨基-β-咔啉，产率通常在良好到优秀之间。通过密度泛函理论（DFT）计算，为这种串联反应（特别是观察到的高区域选择性）提供了一个合理的机理。
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