克罗地亚首次成功控制产KPC肺炎克雷伯菌疫情。
Successful containment of the first KPC-producing Klebsiella pneumoniae outbreak in Croatia.
作者信息
Brkic Dijana Varda, Pristas Irina, Cipris Ivan, Jelic Marko, Butic Iva, Andrasevic Arjana Tambic
机构信息
University Hospital Centre Zagreb, Department of Clinical Microbiology, 10000 Zagreb, Croatia.
University Hospital for Infectious Diseases, Department of Clinical Microbiology, 10000 Zagreb, Croatia.
出版信息
Future Microbiol. 2017 Sep;12:967-974. doi: 10.2217/fmb-2016-0143. Epub 2017 Aug 10.
AIM
We report the first outbreak caused by Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae sequence type 258 (ST 258) clone that occurred in Croatia from May to December 2012.
MATERIALS & METHODS: 23 carbapenem-resistant K. pneumoniae isolates were recovered from clinical and screening specimens of 12 patients hospitalized in a regional hospital. The first isolates from the 12 patients were typed using pulsed-field gel electrophoresis and multilocus sequence typing.
RESULTS
PCR detection showed that all isolates harbored the bla gene, together with bla and bla .
CONCLUSION
The rapid detection of KPC-producing K. pneumoniae and vigorous implementation of infection control measures were necessary to successfully control the outbreak.
目的
我们报告了2012年5月至12月在克罗地亚发生的首例由产肺炎克雷伯菌碳青霉烯酶（KPC）的肺炎克雷伯菌序列型258（ST 258）克隆引起的疫情。
材料与方法
从一家地区医院住院的12名患者的临床和筛查标本中分离出23株耐碳青霉烯类肺炎克雷伯菌。使用脉冲场凝胶电泳和多位点序列分型对这12名患者的首批分离株进行分型。
结果
PCR检测显示，所有分离株均携带bla基因，以及bla和bla。
结论
快速检测产KPC的肺炎克雷伯菌并大力实施感染控制措施对于成功控制疫情很有必要。
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