反对血管活性肠肽作为支配小鼠结肠纵肌的非肾上腺素能、非胆碱能神经中的抑制性递质的证据。
Evidence against VIP as the inhibitory transmitter in non-adrenergic, non-cholinergic nerves supplying the longitudinal muscle of the mouse colon.
作者信息
Fontaine J, Grivegnee A R, Robberecht P
出版信息
Br J Pharmacol. 1986 Nov;89(3):599-602. doi: 10.1111/j.1476-5381.1986.tb11161.x.
Abstract
Vasoactive intestinal peptide (VIP) had two types of effects on the longitudinal muscle of the mouse distal colon. At low concentrations (10(-8) M) VIP induced a contraction which seemed to be related to the production of prostaglandins as it was abolished after preincubation with indomethacin (10(-6) M). At higher concentrations (3 X 10(-8) and 10(-7) M) VIP induced relaxations which developed slowly and were related to stimulation of the adenylate cyclase activity of the smooth muscle cells. There is no evidence that VIP is the non-adrenergic, non-cholinergic transmitter released by electrical stimulation in this preparation and responsible for rapid relaxation of the smooth muscle.
摘要
血管活性肠肽（VIP）对小鼠远端结肠的纵行肌有两种作用。低浓度（10⁻⁸ M）时，VIP引起收缩，这种收缩似乎与前列腺素的产生有关，因为在与吲哚美辛（10⁻⁶ M）预孵育后收缩被消除。高浓度（3×10⁻⁸和10⁻⁷ M）时，VIP引起缓慢发展的舒张，这与平滑肌细胞腺苷酸环化酶活性的刺激有关。没有证据表明VIP是该制剂中电刺激释放的非肾上腺素能、非胆碱能递质，且是负责平滑肌快速舒张的递质。
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本文引用的文献
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2
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Biochim Biophys Acta. 1981 Nov 18;678(1):83-90. doi: 10.1016/0304-4165(81)90050-7.
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Vasoactive intestinal polypeptide: increased tone, enhancement of acetylcholine release, and stimulation of adenylate cyclase in intestinal smooth muscle.血管活性肠肽：增加张力、增强乙酰胆碱释放并刺激肠道平滑肌中的腺苷酸环化酶。
Life Sci. 1980 Mar 10;26(10):811-22. doi: 10.1016/0024-3205(80)90288-x.
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