帕金森病大鼠模型中移植培养的人交感神经元后的功能恢复
Functional recovery in a rat model of Parkinson's disease following transplantation of cultured human sympathetic neurons.
作者信息
Kamo H, Kim S U, McGeer P L, Shin D H
出版信息
Brain Res. 1986 Nov 12;397(2):372-6. doi: 10.1016/0006-8993(86)90641-4.
PMID:2879605
Abstract
Rats subjected to a unilateral 6-hydroxydopamine (6-OHDA)-induced lesion of the nigrostriatal dopamine pathway were given transplants of cultured fetal human sympathetic neurons. Amphetamine-induced turning behavior in these rats was reversed by the transplants after 1.5-4.5 months. The presence of transplanted neurons and their processes was demonstrated by immunohistochemistry for tyrosine hydroxylase.
摘要
对遭受单侧6-羟基多巴胺（6-OHDA）诱导的黑质纹状体多巴胺能通路损伤的大鼠进行培养的人胎儿交感神经元移植。在1.5至4.5个月后，这些大鼠中安非他明诱导的旋转行为被移植所逆转。通过酪氨酸羟化酶免疫组织化学证明了移植神经元及其突起的存在。
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