A computer-aided 3-dimensional (3D) visualization operation simulation system based on computer-aided design (CAD) Unigraphics NX and Mimics software was established to provide orthopedic surgeons with an actual and reliable system in treating of distal femoral fracture.According to the preoperative CT data, 3D reconstruction of the distal femoral fracture could be achieved by the Mimics software. Then, the CAD Unigraphics NX software was used to measure the model function of all the related surgical instruments, including less invasive stabilization system (LISS) and retrograde intramedullary nail fixation.The function of CAD Unigraphics NX and Mimics software was successful in assisting in the treatment of distal femoral fracture with LISS and retrograde intramedullary nail fixation. The operation procedure was actual, visualized, and lifelike. Moreover, the operation effect could be estimated before surgery.The virtual surgery system may improve the reliability and safety of the operative care of distal femoral fracture.