Nikolarakis K E, Almeida O F, Herz A
Brain Res. 1986 Dec 3;399(1):152-5. doi: 10.1016/0006-8993(86)90610-4.
Corticotropin-releasing factor (CRF) at doses of 10(-12)-10(-8) M significantly stimulated the release of beta-endorphin and dynorphin from superfused rat hypothalamic slices. These effects were shown to be mediated by the CRF receptor since they were antagonized by the CRF receptor antagonist alpha-helical CRF9-41 (10(-6) M). The two opioid peptides showed different time courses of response and in the case of beta-endorphin, an attenuation of the response upon continued exposure to CRF was observed.
剂量为10⁻¹² - 10⁻⁸ M的促肾上腺皮质激素释放因子（CRF）显著刺激了经体外灌流的大鼠下丘脑切片中β-内啡肽和强啡肽的释放。这些作用被证明是由CRF受体介导的，因为它们被CRF受体拮抗剂α-螺旋CRF9 - 41（10⁻⁶ M）所拮抗。这两种阿片肽表现出不同的反应时间进程，就β-内啡肽而言，观察到持续暴露于CRF后反应减弱。
