抽动秽语综合征中的缄默症：大麻类药物改善了两名患者的严重发声阻滞性抽动。
Speechlessness in Gilles de la Tourette Syndrome: Cannabis-Based Medicines Improve Severe Vocal Blocking Tics in Two Patients.
作者信息
Jakubovski Ewgeni, Müller-Vahl Kirsten
机构信息
Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
出版信息
Int J Mol Sci. 2017 Aug 10;18(8):1739. doi: 10.3390/ijms18081739.
Abstract
We report the cases of two young German male patients with treatment-resistant Tourette syndrome (TS), who suffer from incapacitating stuttering-like speech disfluencies caused by vocal blocking tics and palilalia. Case 1: a 19-year old patient received medical cannabis at a dose of 1 × 0.1 g cannabis daily. Case 2: a 16-year old patient initially received dronabinol at a maximum dose of 22.4-33.6 mg daily. Both treatments provided significant symptom improvement of vocal blocking tics as well as of comorbid conditions and were well tolerated. Thus, cannabis-based medicine appears to be effective in treatment-resistant TS patients with vocal blocking tics.
摘要
我们报告了两名患有难治性图雷特综合征（TS）的年轻德国男性患者的病例，他们因发声阻塞性抽动和复述语言而患有严重的口吃样言语不流畅。病例1：一名19岁患者每天接受1×0.1克大麻的医用大麻治疗。病例2：一名16岁患者最初接受最大剂量为每日22.4 - 33.6毫克的屈大麻酚治疗。两种治疗方法均使发声阻塞性抽动以及共病症状得到显著改善，且耐受性良好。因此，基于大麻的药物似乎对患有发声阻塞性抽动的难治性TS患者有效。
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