抽动秽语综合征中的缄默症：大麻类药物改善了两名患者的严重发声阻滞性抽动。
Speechlessness in Gilles de la Tourette Syndrome: Cannabis-Based Medicines Improve Severe Vocal Blocking Tics in Two Patients.
作者信息
Jakubovski Ewgeni, Müller-Vahl Kirsten
机构信息
Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
出版信息
Int J Mol Sci. 2017 Aug 10;18(8):1739. doi: 10.3390/ijms18081739.
Abstract
We report the cases of two young German male patients with treatment-resistant Tourette syndrome (TS), who suffer from incapacitating stuttering-like speech disfluencies caused by vocal blocking tics and palilalia. Case 1: a 19-year old patient received medical cannabis at a dose of 1 × 0.1 g cannabis daily. Case 2: a 16-year old patient initially received dronabinol at a maximum dose of 22.4-33.6 mg daily. Both treatments provided significant symptom improvement of vocal blocking tics as well as of comorbid conditions and were well tolerated. Thus, cannabis-based medicine appears to be effective in treatment-resistant TS patients with vocal blocking tics.
摘要
我们报告了两名患有难治性图雷特综合征（TS）的年轻德国男性患者的病例，他们因发声阻塞性抽动和复述语言而患有严重的口吃样言语不流畅。病例1：一名19岁患者每天接受1×0.1克大麻的医用大麻治疗。病例2：一名16岁患者最初接受最大剂量为每日22.4 - 33.6毫克的屈大麻酚治疗。两种治疗方法均使发声阻塞性抽动以及共病症状得到显著改善，且耐受性良好。因此，基于大麻的药物似乎对患有发声阻塞性抽动的难治性TS患者有效。
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本文引用的文献
1
Blocking Phenomena in Gilles de la Tourette Syndrome.
Mov Disord Clin Pract. 2015 Jun 30;2(4):438-439. doi: 10.1002/mdc3.12199. eCollection 2015 Dec.
2
Significant Tic Reduction in An Otherwise Treatment-Resistant Patient with Gilles de la Tourette Syndrome Following Treatment with Nabiximols.
Brain Sci. 2017 Apr 26;7(5):47. doi: 10.3390/brainsci7050047.
3
New Insights into Clinical Characteristics of Gilles de la Tourette Syndrome: Findings in 1032 Patients from a Single German Center.
Front Neurosci. 2016 Sep 12;10:415. doi: 10.3389/fnins.2016.00415. eCollection 2016.
4
Severe motor and vocal tics controlled with Sativex®.
Australas Psychiatry. 2016 Dec;24(6):541-544. doi: 10.1177/1039856216663737. Epub 2016 Aug 24.
5
Prevalence of tic disorders: a systematic review and meta-analysis.
Pediatr Neurol. 2012 Aug;47(2):77-90. doi: 10.1016/j.pediatrneurol.2012.05.002.
6
Effective treatment of Tourette's syndrome with marijuana.
J Psychopharmacol. 1993 Jan;7(4):389-91. doi: 10.1177/026988119300700411.
7
Cannabinoids improve driving ability in a Tourette's patient.
Psychiatry Res. 2011 Dec 30;190(2-3):382. doi: 10.1016/j.psychres.2011.05.033. Epub 2011 Jun 12.
8
European clinical guidelines for Tourette syndrome and other tic disorders. Part III: behavioural and psychosocial interventions.
Eur Child Adolesc Psychiatry. 2011 Apr;20(4):197-207. doi: 10.1007/s00787-011-0167-3.
9
European clinical guidelines for Tourette syndrome and other tic disorders. Part II: pharmacological treatment.
Eur Child Adolesc Psychiatry. 2011 Apr;20(4):173-96. doi: 10.1007/s00787-011-0163-7.
10
Oral delta 9-tetrahydrocannabinol improved refractory Gilles de la Tourette syndrome in an adolescent by increasing intracortical inhibition: a case report.
J Clin Psychopharmacol. 2010 Apr;30(2):190-2. doi: 10.1097/JCP.0b013e3181d236ec.
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