Hematology Department, Fondazione Policlinico Agostino Gemelli, Rome, Italy.
Molecular Biology and HLA Typing Laboratory, Fondazione Policlinico Agostino Gemelli, Rome, Italy.
Eur J Clin Invest. 2017 Oct;47(10):711-718. doi: 10.1111/eci.12796. Epub 2017 Sep 5.
GvHD is one of the major complication after stem cell transplantation affecting transplant-related mortality. Throughout the last years, many serum proteins were been proposed as possible biomarkers for GvHD.
We studied the trend of five of the most studied serum proteins to evaluate whether a correlation exists between proteins concentration and post-HSCT outcomes.
We measured serum concentration of REG3α, ST2, B-cell activating factor (BAFF), CXCL9 and elafin in a cohort of 77 patients submitted to Hematopoietic allogeneic stem cell transplantation (HSCT) in our department. Blood samples were been collected at baseline, day +30, GvHD onset and GvHD resolution.
REG3α levels showed an association only with acute GvHD. Elafin and ST2 levels varied according to both acute and chronic GvHD occurrence. BAFF concentration showed an inverse association with acute GvHD development. Interestingly, baseline BAFF and ST2 levels predicted post-HSCT survival. No associations were found for CXCL9.
Except for CXCL9, the protein levels seem to change according to GvHD development, independently from organ involvement and grading. Pretransplant ST2 and BAFF appeared to be predictors for survival after HSCT.
移植物抗宿主病（GvHD）是造血干细胞移植后影响移植相关死亡率的主要并发症之一。在过去的几年中，许多血清蛋白被提出作为 GvHD 的可能生物标志物。
我们研究了五种研究最多的血清蛋白的趋势，以评估蛋白浓度与 post-HSCT 结果之间是否存在相关性。
我们在我院接受造血同种异体干细胞移植（HSCT）的 77 例患者的队列中测量了 REG3α、ST2、B 细胞激活因子（BAFF）、CXCL9 和弹性蛋白酶抑制剂（elafin）的血清浓度。在基线、第 30 天、GvHD 发病和 GvHD 缓解时采集血液样本。
REG3α 水平仅与急性 GvHD 有关。elafin 和 ST2 水平根据急性和慢性 GvHD 的发生而变化。BAFF 浓度与急性 GvHD 的发生呈负相关。有趣的是，基线 BAFF 和 ST2 水平预测 post-HSCT 生存。未发现 CXCL9 的相关性。
除了 CXCL9 之外，蛋白水平似乎根据 GvHD 的发展而变化，与器官受累和分级无关。移植前 ST2 和 BAFF 似乎是 HSCT 后生存的预测因素。
