Lindåse S, Nostell K, Söder J, Bröjer J
Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden.
J Vet Intern Med. 2017 Sep;31(5):1541-1550. doi: 10.1111/jvim.14799. Epub 2017 Aug 10.
A hyperbolic relationship between β-cell response and insulin sensitivity (IS) has been described in several species including rodents, dogs, and humans. This relationship has not been elucidated in the horse.
HYPOTHESIS/OBJECTIVES: To determine whether the hyperbolic relationship between β-cell response and IS exists in horses by using indices of β-cell response from the oral sugar test (OST) and IS measurements from the euglycemic hyperinsulinemic clamp (EHC). A second aim was to compare how well IS estimates from the OST and EHC correlate.
Forty-nine horses with different degrees of insulin regulation (normal-to-severe insulin dysregulation).
Cross-sectional study. Horses were examined with an OST and an EHC.
Decreased IS was associated with increased β-cell response in the horses. Nine of 12 comparisons between indices of β-cell response and IS measures fulfilled the criteria for a hyperbolic relationship. Indices of IS calculated from the OST correlated highly with the insulin-dependent glucose disposal rate (M) and the insulin-dependent glucose disposal rate per unit of insulin (M/I) determined from the EHC (r = 0.81-0.87).
A hyperbolic relationship between β-cell response and IS exists in horses, which suggest that horses with insulin dysregulation respond not only with postprandial hyperinsulinemia but are also insulin resistant. The OST is primarily a test for β-cell response rather than a test for IS, but calculated indices of IS from the OST may be useful to estimate IS in horses, especially when the horse is insulin resistant.
在包括啮齿动物、狗和人类在内的多个物种中，已描述了β细胞反应与胰岛素敏感性（IS）之间的双曲线关系。但在马中尚未阐明这种关系。
假设/目标：通过使用口服糖试验（OST）的β细胞反应指标和正常血糖高胰岛素钳夹试验（EHC）的IS测量值，确定马中β细胞反应与IS之间是否存在双曲线关系。第二个目的是比较OST和EHC的IS估计值之间的相关性。
49匹胰岛素调节程度不同（从正常到严重胰岛素调节异常）的马。
横断面研究。对马进行OST和EHC检查。
在马中，IS降低与β细胞反应增加相关。β细胞反应指标与IS测量值之间的12项比较中有9项符合双曲线关系标准。从OST计算的IS指标与从EHC确定的胰岛素依赖性葡萄糖处置率（M）和每单位胰岛素的胰岛素依赖性葡萄糖处置率（M/I）高度相关（r = 0.81 - 0.87）。
马中存在β细胞反应与IS之间的双曲线关系，这表明胰岛素调节异常的马不仅会出现餐后高胰岛素血症，而且还存在胰岛素抵抗。OST主要是一种β细胞反应测试，而非IS测试，但从OST计算的IS指标可能有助于估计马的IS，特别是当马存在胰岛素抵抗时。
