β受体阻滞剂的临床应用

Clinical aspects of beta-blockade.

作者信息

Smith U

出版信息

Cephalalgia. 1986;6 Suppl 5:55-7. doi: 10.1177/03331024860060S507.

Abstract

beta-Blocking drugs have no or only a partial beta-agonistic activity (ISA). Since they all bind to beta receptors, they act as competitive inhibitors of the endogenous catecholamines. In addition to this common effect, the beta-blocking drugs also have other properties that may be clinically important, such as extent of beta 1 selectivity, ISA, and lipophilicity. The importance of these properties in the clinical setting is reviewed.

摘要

β受体阻滞剂没有或仅有部分β激动活性（内在拟交感活性）。由于它们都与β受体结合，因此作为内源性儿茶酚胺的竞争性抑制剂发挥作用。除了这种共同作用外，β受体阻滞剂还具有其他一些可能在临床上具有重要意义的特性，如β1选择性程度、内在拟交感活性和脂溶性。本文综述了这些特性在临床环境中的重要性。