Department of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, Liaoning, China.
Cardiovasc Diabetol. 2017 Aug 10;16(1):101. doi: 10.1186/s12933-017-0585-8.
Inflammatory response, oxidative stress, and endoplasmic reticulum (ER) stress are important pathophysiological bases of the occurrence and development of diabetes mellitus (DM) and macroangiopathy complications. Selenoprotein S (SELENOS) is involved in the regulation of these mechanisms; therefore, its association with DM and macroangiopathy has gradually received attention from scholars worldwide. SELENOS has different biological functions in different tissues and organs: it exerts antioxidant protection and has anti-ER stress effects in the pancreas and blood vessels, while it promotes the occurrence and development of insulin resistance in the liver, adipose tissue, and skeletal muscle. In addition, studies have confirmed that some SELENOS gene polymorphisms can influence the inflammatory response and are closely associated with the risk for developing DM and macroangiopathy. Therefore, comprehensive understanding of the association between SELENOS and inflammation, oxidative stress, and ER stress may better elucidate and supplement the pathogenic mechanisms of DM and macroangiopathy complications. Furthermore, in-depth investigation of the association of SELENOS function in different tissues and organs with DM and macroangiopathy may facilitate the development of new strategies for the prevention and treatment of DM and macrovascular complications. Here, we summarize the consensus and controversy regarding functions of SELENOS on currently available evidence.
炎症反应、氧化应激和内质网（ER）应激是糖尿病（DM）和大血管并发症发生和发展的重要病理生理基础。硒蛋白 S（SELENOS）参与这些机制的调节；因此，其与 DM 和大血管病变的关系逐渐受到全球学者的关注。SELENOS 在不同的组织和器官中具有不同的生物学功能：它在胰腺和血管中发挥抗氧化保护和抗 ER 应激作用，而在肝脏、脂肪组织和骨骼肌中则促进胰岛素抵抗的发生和发展。此外，研究已经证实，一些 SELENOS 基因多态性可以影响炎症反应，并与发生 DM 和大血管病变的风险密切相关。因此，全面了解 SELENOS 与炎症、氧化应激和 ER 应激之间的关系，可能更好地阐明和补充 DM 和大血管并发症的发病机制。此外，深入研究 SELENOS 在不同组织和器官中的功能与 DM 和大血管病变的关系，可能有助于制定预防和治疗 DM 和大血管并发症的新策略。在这里，我们根据现有证据总结了 SELENOS 功能的共识和争议。
