激素替代疗法：青春之泉？

Hormone Replacement: The Fountain of Youth?

作者信息

Williams Bradley R, Cho Janet Soojeung

机构信息

Titus Family Department of Clinical Pharmacy, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA 90089-9121, USA.

USC Specialty Pharmacy, University of Southern California, School of Pharmacy, 1000 South Fremont Avenue, A-10, Suite 10150, Alhambra, CA 91803, USA.

出版信息

Prim Care. 2017 Sep;44(3):481-498. doi: 10.1016/j.pop.2017.04.006.

DOI:10.1016/j.pop.2017.04.006

PMID:28797374

Abstract

Natural aging brings reduced production of growth and sex hormones, beginning in middle age, with noticeable physiologic changes by the sixth or seventh decade of life: reduced muscle mass, energy, and exercise capacity and alterations in sexual function. Hormones and hormone precursors have been investigated to delay changes in body composition, strength, and physical and cognitive function. Menopausal hormone therapy is effective for vasomotor and genitourinary symptoms. Testosterone is effective in men with hypogonadism and declines in physiologic function. The lack of clinical studies evaluating the long-term effects and risks of hormone replacement limits its use.

摘要

自然衰老会导致生长激素和性激素的分泌减少，从中年开始，到生命的第六或第七个十年会出现明显的生理变化：肌肉量减少、精力下降、运动能力降低以及性功能改变。人们对激素和激素前体进行了研究，以延缓身体成分、力量以及身体和认知功能的变化。绝经激素治疗对血管舒缩症状和泌尿生殖系统症状有效。睾酮对性腺功能减退和生理功能下降的男性有效。缺乏评估激素替代长期影响和风险的临床研究限制了其应用。