Tuzcu Sadiye Altun, Pekkolay Zafer, Kılınç Faruk, Tuzcu Alpaslan Kemal
Department of Nuclear Medicine, Gazi Yasargil Education and Research Hospital, Diyarbakır, Turkey; and
Department of Endocrinology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
J Nucl Med Technol. 2017 Sep;45(3):198-200. doi: 10.2967/jnmt.117.192708. Epub 2017 Aug 10.
Insulinomas are the most common cause of hypoglycemia, resulting from endogenous hyperinsulinism. The diagnosis of insulinoma is established by demonstrating inappropriately high serum insulin concentrations during a spontaneous or induced episode of hypoglycemia. Most insulinomas are islet-cell tumors. They are often small (<2 cm), benign, and difficult to localize with current imaging techniques. Insulinomas can be detected using either noninvasive procedures (e.g., transabdominal ultrasonography, spiral CT, MRI, In-pentetreotide imaging, and F-l-dihydroxyphenylalanine PET) or invasive procedures (e.g., endoscopic ultrasonography) or a selective arterial calcium stimulation test with hepatic venous sampling. We performed Ga-DOTATATE PET/CT on 3 patients with insulinoma. All patients' insulinomas were shown clearly with Ga-DOTATATE PET/CT. Ga-DOTATATE PET/CT imaging may be a useful noninvasive imaging technique to localize insulinomas preoperatively.
胰岛素瘤是低血糖最常见的病因，由内源性高胰岛素血症引起。胰岛素瘤的诊断是通过在自发性或诱发性低血糖发作期间证明血清胰岛素浓度异常升高来确立的。大多数胰岛素瘤是胰岛细胞瘤。它们通常较小（<2 cm），为良性，并且使用当前的成像技术难以定位。胰岛素瘤可以使用非侵入性检查（如经腹超声、螺旋CT、MRI、铟标记的奥曲肽显像和氟代多巴PET）或侵入性检查（如内镜超声）或选择性动脉钙刺激试验及肝静脉采血来检测。我们对3例胰岛素瘤患者进行了镓标记的奥曲肽PET/CT检查。所有患者的胰岛素瘤在镓标记的奥曲肽PET/CT检查中均清晰显示。镓标记的奥曲肽PET/CT成像可能是术前定位胰岛素瘤的一种有用的非侵入性成像技术。
