Ali Aliaa A, Gomaa Nancy A S, Awadein Ahmed R, Al-Hayouti Huda H, Hegazy Ahmed I
Department of Paediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.
Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Acta Paediatr. 2017 Dec;106(12):1919-1927. doi: 10.1111/apa.14019. Epub 2017 Sep 18.
This study described the characteristics and risk factors of neonates who developed retinopathy of prematurity (ROP) and severe treatable ROP in two Egyptian neonatal intensive care units (NICUs).
This retrospective cohort study comprised 108 preterm neonates who were screened for ROP after being admitted to the two NICUs run by Cairo University Hospital from June 2014 to May 2015. Patients were examined using digital fundus photography and indirect ophthalmoscopy was performed if ROP was detected.
Retinopathy of prematurity occurred in 75 patients. Late-onset sepsis, ventilation and hypercapnia were independently associated with ROP. Patients who developed severe treatable ROP had a younger gestational age (GA) than patients who did not develop ROP or developed mild or moderate ROP (29 weeks, range 27-33 weeks versus 32 weeks, range 28-36 weeks, p = 0.002) and a lower birthweight (1200 g, range 980-1590 g versus 1460 g, range 770-2475 g, p = 0.029). The risk factors associated with severe treatable ROP included the duration of admission, the duration of incubator oxygen, late-onset sepsis, intraventricular haemorrhage, total parenteral nutrition and the duration of caffeine citrate therapy.
This study showed that the risks for ROP were wide-ranging and included GA and weight, medical conditions and treatment.
本研究描述了埃及两家新生儿重症监护病房（NICU）中发生早产儿视网膜病变（ROP）及严重可治疗性ROP的新生儿的特征和危险因素。
这项回顾性队列研究纳入了2014年6月至2015年5月入住开罗大学医院两所NICU后接受ROP筛查的108例早产儿。使用数字眼底摄影对患者进行检查，若检测到ROP则进行间接检眼镜检查。
75例患者发生了早产儿视网膜病变。迟发性败血症、通气和高碳酸血症与ROP独立相关。发生严重可治疗性ROP的患者的胎龄（GA）低于未发生ROP或发生轻度或中度ROP的患者（29周，范围27 - 33周对32周，范围28 - 36周，p = 0.002），且出生体重更低（1200 g，范围980 - 1590 g对1460 g，范围770 - 2475 g，p = 0.029）。与严重可治疗性ROP相关的危险因素包括住院时间、暖箱吸氧时间、迟发性败血症、脑室内出血、全胃肠外营养和枸橼酸咖啡因治疗时间。
本研究表明，ROP的风险范围广泛，包括胎龄和体重、医疗状况及治疗。
