Maeda Hajime, Go Hayato, Iwasa Hajime, Hiruta Shun, Ichikawa Hirotaka, Sugano Yukinori, Ogasawara Kei, Momoi Nobuo, Sekiryu Tetsuju, Hosoya Mitsuaki
Department of Pediatrics, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
Department of Public Health, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Sci Rep. 2025 Jan 2;15(1):264. doi: 10.1038/s41598-024-84030-x.
Retinopathy of prematurity (ROP) is a major cause of preventable blindness in preterm infants. The association between red blood cell (RBC) parameters and the development of ROP remains unclear. The objectives of the present study were to evaluate the association between RBC parameters and ROP treatment. This single-center, retrospective cohort study included preterm infants born at < 30 weeks of gestation. Data pertaining to RBC parameters and ROP treatment were obtained from the medical records. A receiver operating characteristic (ROC) analysis was performed to determine the cut-off values of the RBC parameters according to the need for ROP treatment. Multiple logistic regression analyses assessed the association between ROP treatment and RBC parameters at birth and on day of life (DOL) 28. We included 202 infants, and 44.1% were treated for ROP. After adjusting for confounders, we observed associations between ROP treatment and mean corpuscular volume (MCV) values > 117.3 fL at birth (adjusted odds ratio [aOR]:2.3; 95% confidence intervals CI 1.0-5.3). Additionally, on DOL 28, hemoglobin (Hb) values < 9.9 g/dL (aOR:3.0; 95% CI 1.4-6.7), hematocrit (Hct) values < 31.0% (aOR:2.7; 95% CI 1.3-5.6), and red cell distribution width (RDW) values > 18.5% (aOR:2.6; 95% CI 1.1-6.2) were associated with ROP treatment. In conclusion, our study indicated that infants born at < 30 weeks of gestation with an MCV > 117.3 fL at birth, along with Hb < 9.9 g/dL, Hct < 31.0%, and RDW > 18.5% on DOL 28, had an increased risk of requiring ROP, warranting treatment.
早产儿视网膜病变（ROP）是导致早产儿可预防性失明的主要原因。红细胞（RBC）参数与ROP发生发展之间的关联尚不清楚。本研究的目的是评估RBC参数与ROP治疗之间的关联。这项单中心回顾性队列研究纳入了孕周<30周出生的早产儿。从病历中获取与RBC参数和ROP治疗相关的数据。进行了受试者工作特征（ROC）分析，以根据ROP治疗需求确定RBC参数的临界值。多因素logistic回归分析评估了ROP治疗与出生时及出生后第28天（DOL 28）的RBC参数之间的关联。我们纳入了202例婴儿，其中44.1%接受了ROP治疗。在对混杂因素进行校正后，我们观察到ROP治疗与出生时平均红细胞体积（MCV）值>117.3 fL之间存在关联（校正比值比[aOR]：2.3；95%置信区间[CI] 1.0 - 5.3）。此外，在DOL 28时，血红蛋白（Hb）值<9.9 g/dL（aOR：3.0；95% CI 1.4 - 6.7）、血细胞比容（Hct）值<31.0%（aOR：2.7；95% CI 1.3 - 5.6）以及红细胞分布宽度（RDW）值>18.5%（aOR：2.6；95% CI 1.1 - 6.2）与ROP治疗相关。总之，我们的研究表明，孕周<30周出生的婴儿，若出生时MCV>117.3 fL，且在DOL 28时Hb<9.9 g/dL、Hct<31.0%以及RDW>18.5%，则发生ROP且需要治疗的风险增加。
