Yang Lu, Dolan Elliott M, Tan Sophia K, Lin Tianyun, Sontag Eduardo D, Khare Sagar D
Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.
Center for Integrative Proteomics Research, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.
Chembiochem. 2017 Oct 18;18(20):2000-2006. doi: 10.1002/cbic.201700425. Epub 2017 Sep 1.
The construction of stimulus-responsive supramolecular complexes of metabolic pathway enzymes, inspired by natural multienzyme assemblies (metabolons), provides an attractive avenue for efficient and spatiotemporally controllable one-pot biotransformations. We have constructed a phosphorylation- and optically responsive metabolon for the biodegradation of the environmental pollutant 1,2,3-trichloropropane.
受天然多酶组装体（代谢体）启发构建的代谢途径酶的刺激响应超分子复合物，为高效且时空可控的一锅法生物转化提供了一条有吸引力的途径。我们构建了一种用于环境污染物1,2,3 - 三氯丙烷生物降解的磷酸化和光响应代谢体。
