杜兴氏肌营养不良症家系中Xp21减数分裂交换点的定位
Localisation of Xp21 meiotic exchange points in Duchenne muscular dystrophy families.
作者信息
Bertelson C J, Bartley J A, Monaco A P, Colletti-Feener C, Fischbeck K, Kunkel L M
出版信息
J Med Genet. 1986 Dec;23(6):531-7. doi: 10.1136/jmg.23.6.531.
Abstract
The inheritance of Duchenne muscular dystrophy in 25 families was studied with 13 X chromosome specific cloned DNA fragments from 10 loci in and surrounding Xp21. When multiple probes were informative, the meiotic exchange points for each meiosis were located in individual families. Neither genetic nor physical evidence indicates an unusually high recombination rate across Xp21 in these 25 families.
摘要
利用来自Xp21及其周围10个位点的13个X染色体特异性克隆DNA片段，对25个家庭中杜氏肌营养不良症的遗传情况进行了研究。当多个探针具有信息性时，在各个家庭中确定了每个减数分裂的减数分裂交换点。无论是遗传学证据还是物理证据，均未表明这25个家庭中Xp21区域的重组率异常高。
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