TCS Research and Innovation, Kolkata 700156, India.
Sensors (Basel). 2017 Aug 11;17(8):1853. doi: 10.3390/s17081853.
Pulmonary ailments are conventionally diagnosed by spirometry. The complex forceful breathing maneuver as well as the extreme cost of spirometry renders it unsuitable in many situations. This work is aimed to facilitate an emerging direction of tidal breathing-based pulmonary evaluation by designing a novel, equitable, precise and portable device for acquisition and analysis of directional tidal breathing patterns, in real time. The proposed system primarily uses an in-house designed blow pipe, 40-kHz air-coupled ultrasound transreceivers, and a radio frequency (RF) phase-gain integrated circuit (IC). Moreover, in order to achieve high sensitivity in a cost-effective design philosophy, we have exploited the phase measurement technique, instead of selecting the contemporary time-of-flight (TOF) measurement; since application of the TOF principle in tidal breathing assessments requires sub-micro to nanosecond time resolution. This approach, which depends on accurate phase measurement, contributed to enhanced sensitivity using a simple electronics design. The developed system has been calibrated using a standard 3-L calibration syringe. The parameters of this system are validated against a standard spirometer, with maximum percentage error below 16%. Further, the extracted respiratory parameters related to tidal breathing have been found to be comparable with relevant prior works. The error in detecting respiration rate only is 3.9% compared to manual evaluation. These encouraging insights reveal the definite potential of our tidal breathing pattern (TBP) prototype for measuring tidal breathing parameters in order to extend the reach of affordable healthcare in rural regions and developing areas.
传统上,肺部疾病是通过肺活量测定法来诊断的。复杂的强制呼吸动作以及肺活量测定法的极高成本,使得它在许多情况下都不适用。本工作旨在通过设计一种新颖、公平、精确和便携式的设备,实时获取和分析定向潮气流式呼吸模式,为新兴的基于潮气流式呼吸的肺部评估方向提供便利。该系统主要使用内部设计的吹管、40kHz 空气耦合超声收发器和射频(RF)相位增益集成电路(IC)。此外,为了在具有成本效益的设计理念中实现高灵敏度,我们利用了相位测量技术,而不是选择当代的飞行时间(TOF)测量技术;因为在潮气流式呼吸评估中应用 TOF 原理需要亚微秒至纳秒的时间分辨率。这种依赖于精确相位测量的方法,通过简单的电子设计提高了灵敏度。该系统已使用标准的 3-L 校准注射器进行校准。该系统的参数与标准肺活量计进行了验证,最大误差百分比低于 16%。此外,所提取的与潮气流式呼吸相关的呼吸参数与相关的先前工作相当。与手动评估相比,检测呼吸频率的误差仅为 3.9%。这些令人鼓舞的见解表明,我们的潮气流式呼吸模式(TBP)原型在测量潮气流式呼吸参数方面具有明确的潜力,以便在农村地区和发展中地区扩大负担得起的医疗保健的覆盖范围。