Department of Chemistry, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
Org Lett. 2017 Sep 1;19(17):4413-4415. doi: 10.1021/acs.orglett.7b02117. Epub 2017 Aug 11.
A catalytic preparation of silyl enol ethers from unactivated secondary alkyl tosylates is reported. An inexpensive cobalt catalyst is used under mild conditions with low pressures of carbon monoxide. Nucleophilic, anionic cobalt carbonyls facilitate the catalytic activation of a range of alkyl tosylates. The silylcarbonylation offers a practical approach to synthetically valuable silyl enol ethers from simple starting materials.
报道了一种从非活化仲烷基对甲苯磺酸酯制备硅基烯醇醚的催化方法。在温和条件下,使用廉价的钴催化剂,在较低的一氧化碳压力下进行反应。亲核的、阴离子的钴羰基化合物有利于催化活化一系列的烷基对甲苯磺酸酯。硅羰化反应为从简单的起始原料合成有价值的硅基烯醇醚提供了一种实用的方法。