Wang Weida, Peng Xiongwen, Liang Cuirong, Chen Hao, Zhang Yingchun, Sun Xiaofei, Shen Leyuan, Lu Yue
Department of Hematology Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.
Department of Clinical Laboratory, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.
Ann Clin Lab Sci. 2017 Aug;47(4):416-421.
Bone marrow involvement in neuroblastoma indicates an advanced stage of the disease. In this study, we retrospectively analyzed the bone marrow infiltration status and hematological parameters of 111 cases of neuroblastoma. Among the 111 cases, 62 (55.9%) exhibited marrow infiltration. Erythrocytopenia, anemia, and thrombocytopenia were significantly (<0.05) associated with marrow infiltration of >10% malignant cells. The evaluation of blood cell count parameters with receiver operating characteristic curves indicated that erythrocytopenia can substantially improve the accurate prediction of the risk of bone marrow involvement with a Youden index of 0.60. The sensitivity and specificity were 90% and 70%, respectively, which correspond to a cut-off value of 4.015×10^12/L. Hematological aspects with diagnostic value are different among neuroblastoma patients with and without bone marrow infiltration.
骨髓受累于神经母细胞瘤提示疾病处于晚期。在本研究中，我们回顾性分析了111例神经母细胞瘤患者的骨髓浸润情况和血液学参数。在这111例患者中，62例（55.9%）出现骨髓浸润。红细胞减少、贫血和血小板减少与恶性细胞浸润>10%的骨髓浸润显著相关（<0.05）。通过受试者工作特征曲线对血细胞计数参数进行评估表明，红细胞减少可显著提高对骨髓受累风险的准确预测，约登指数为0.60。敏感性和特异性分别为90%和70%，对应的截断值为4.015×10^12/L。有骨髓浸润和无骨髓浸润的神经母细胞瘤患者具有诊断价值的血液学方面有所不同。
