Department of Psychology, Center for Lifespan Changes in Brain and Cognition (LCBC), University of Oslo, Blindern, POB 1094, 0317, Oslo, Norway.
Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway.
Brain Struct Funct. 2018 Jan;223(1):285-296. doi: 10.1007/s00429-017-1493-0. Epub 2017 Aug 11.
Intellectual abilities are supported by a large-scale fronto-parietal brain network distributed across both cerebral hemispheres. This bihemispheric network suggests a functional relevance of inter-hemispheric coordination, a notion which is supported by a series of recent structural magnetic resonance imaging (MRI) studies demonstrating correlations between intelligence scores (IQ) and corpus-callosum anatomy. However, these studies also reveal an age-related dissociation: mostly positive associations are reported in adult samples, while negative associations are found in developing samples. In the present study, we re-examine the association between corpus callosum and intelligence measures in a large (734 datasets from 495 participants) developmental mixed cross-sectional and longitudinal sample (6.4-21.9 years) using raw test scores rather than deviation IQ measures to account for the ongoing cognitive development in this age period. Analyzing mid-sagittal measures of regional callosal thickness, a positive association in the splenium of the corpus callosum was found for both verbal and performance raw test scores. This association was not present when the participants' age was considered in the analysis. Thus, we did not reveal any association that cannot be explained by a temporal co-occurrence of overall developmental trends in intellectual abilities and corpus callosum maturation in the present developing sample.
智力能力由分布在两个大脑半球的大规模额顶叶大脑网络支持。这个双半球网络表明了半球间协调的功能相关性，这一概念得到了一系列最近的结构磁共振成像（MRI）研究的支持，这些研究表明智力分数（IQ）和胼胝体解剖结构之间存在相关性。然而，这些研究也揭示了与年龄相关的分离：在成年样本中报告了主要是正相关，而在发展中的样本中则发现了负相关。在本研究中，我们使用原始测试分数（而不是偏差智商测量值）来解释该年龄段正在进行的认知发展，在一个大型（495 名参与者的 734 个数据集）发展性混合横断面和纵向样本（6.4-21.9 岁）中重新检验胼胝体与智力测量值之间的关联。分析区域胼胝体厚度的中线矢状测量值，发现胼胝体压部的言语和表现原始测试分数呈正相关。当在分析中考虑参与者的年龄时，这种关联就不存在了。因此，我们没有发现任何不能用智力能力和胼胝体成熟的整体发展趋势的时间相关性来解释的关联。
