Fuller N R, Burns J, Sainsbury A, Horsfield S, da Luz F, Zhang S, Denyer G, Markovic T P, Caterson I D
The Boden Institute, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.
Clin Obes. 2017 Dec;7(6):354-359. doi: 10.1111/cob.12208. Epub 2017 Aug 11.
The prevalence of depression in those with obesity is reported to be as high as double that in individuals of normal weight. There is potentially a bi-directional relationship between obesity and depression. Some research has suggested that depression results in weight gain and obesity, and other studies have suggested that those with obesity are more likely to develop depression at a later stage. The aim of this study was to investigate the association of depression symptoms with weight change over a 12-month study. Seventy participants undertook a 3-month lifestyle (diet and exercise) weight loss intervention, and were followed up as part of a 12-month study. Participants completed the Beck Depression Inventory-II (BDI-II) and had their body weight measured throughout the study. Baseline body mass index (BMI) of participants (mean ± standard deviation [SD]) was 31.1 ± 3.9 kg m , body weight was 89.4 ± 16.1 kg, and age was 45.4 ± 11.1 years; 63% of the cohort were female. The mean weight change from baseline to 3 months was -5.2% (±SD 4.3%), and from baseline to 12 months was -4.2% (±SD 6.1%). There was a significant decrease in BDI-II scores over the 12-month study, and a 1-unit decrease in BDI-II score was associated with a further decrease in body weight of -0.4%. The current study indicated that weight loss was associated with improvements in mood for non-clinically depressed individuals with obesity, and these improvements persisted during a period of 3-12 months of follow-up.
据报道，肥胖者中抑郁症的患病率高达正常体重者的两倍。肥胖与抑郁症之间可能存在双向关系。一些研究表明，抑郁症会导致体重增加和肥胖，而其他研究则表明，肥胖者在后期更有可能患上抑郁症。本研究的目的是调查在为期12个月的研究中抑郁症症状与体重变化之间的关联。70名参与者进行了为期3个月的生活方式（饮食和运动）减肥干预，并作为12个月研究的一部分进行随访。参与者完成了贝克抑郁量表第二版（BDI-II），并在整个研究过程中测量了体重。参与者的基线体重指数（BMI）（平均值±标准差[SD]）为31.1±3.9kg/m²，体重为89.4±16.1kg，年龄为45.4±11.1岁；63%的队列是女性。从基线到3个月的平均体重变化为-5.2%（±标准差4.3%），从基线到12个月的平均体重变化为-4.2%（±标准差6.1%）。在为期12个月的研究中，BDI-II得分显著下降，BDI-II得分每下降1个单位，体重进一步下降-0.4%。当前研究表明，减肥与肥胖非临床抑郁症患者的情绪改善有关，并且这些改善在3至12个月的随访期内持续存在。
