Wilson Lauren M, Beasley Knox J, Sorrells Timothy C, Johnson Viviana V
Eastern Virginia Medical School, Norfolk, Virginia.
Department of Dermatology, McDonald Army Health Center, Ft. Eustis, Virginia.
J Cutan Pathol. 2017 Nov;44(11):974-977. doi: 10.1111/cup.13027. Epub 2017 Sep 6.
Neurocristic cutaneous hamartomas (NCH) are rare, pigmented skin lesions derived from the abnormal migration of neural crest cells. We report the case of a 57-year-old female with a congenital localized area of poliosis and underlying pigmented patch on her scalp. Analysis of 2 punch biopsies yielded features consistent with NCH. Histopathology revealed schwannian-differentiated spindle cells and melanocytic components in the dermis. The spindle cells stained positively for S-100 and the stroma showed a prominent CD34 staining. The melanocytes were positive for melanoma triple stain (HMB-45, Melan A, Tyrosinase) and S-100. As the presentation of NCH and focal poliosis has yet to be described, we will present a literature review of NCH and discuss common features and associations of poliosis.
神经嵴性皮肤错构瘤（NCH）是一种罕见的色素沉着性皮肤病变，由神经嵴细胞异常迁移所致。我们报告一例57岁女性病例，其头皮有先天性局限性白发区及下方色素沉着斑。对2次钻孔活检的分析结果符合NCH特征。组织病理学显示真皮中有雪旺氏分化的梭形细胞和黑素细胞成分。梭形细胞S-100染色呈阳性，间质CD34染色显著。黑素细胞黑色素瘤三联染色（HMB-45、Melan A、酪氨酸酶）及S-100呈阳性。由于NCH与局限性白发的表现尚未见报道，我们将对NCH进行文献综述，并讨论白发的常见特征及相关性。
