Romano Ryan C, Fritchie Karen J
Department of Dermatology, Mayo Clinic, Gonda 16, 200 First Street Southwest, Rochester, MN 55905, USA.
Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Mayo Clinic, Hilton 11, 200 First Street Southwest, Rochester, MN 55905, USA.
Clin Lab Med. 2017 Sep;37(3):603-631. doi: 10.1016/j.cll.2017.05.007. Epub 2017 Jun 15.
Fibrohistiocytic tumors are a diverse group of reactive and neoplastic lesions including xanthoma, fibrous histiocytoma and its variants, solitary xanthogranuloma, dermatofibrosarcoma protuberans, and atypical fibroxanthoma. This article reviews some of the more commonly encountered fibrohistiocytic tumors with an emphasis on clinical presentation, macroscopic and histologic characteristics, molecular/cytogenetic findings where applicable, and differential diagnoses.
纤维组织细胞肿瘤是一组多样的反应性和肿瘤性病变,包括黄瘤、纤维组织细胞瘤及其变体、孤立性黄色肉芽肿、隆突性皮肤纤维肉瘤和非典型纤维黄色瘤。本文回顾了一些较常见的纤维组织细胞肿瘤,重点介绍其临床表现、大体和组织学特征、适用时的分子/细胞遗传学发现以及鉴别诊断。