Cardiovascular and Metabolic Disease, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.
Cardiovascular and Metabolic Disease, MedImmune Ltd, Granta Park, Cambridge CB21 6GH, UK.
Curr Opin Pharmacol. 2017 Dec;37:10-15. doi: 10.1016/j.coph.2017.07.010. Epub 2017 Aug 10.
Gut hormones have long been understood to regulate food intake and metabolism. Bariatric surgery significantly elevates circulating gut hormone levels and is proven to affect acute remission of type 2 diabetes before any weight loss is observed. Subsequent weight loss is accrued over weeks to months but is sustained into the long term. Hence, there exists great enthusiasm to recapitulate these changes in gut hormones in the form of novel combination drugs for type 2 diabetes and obesity.
肠道激素一直被认为可以调节食物摄入和新陈代谢。减重手术显著提高了循环肠道激素水平，并被证明可以在观察到体重减轻之前影响 2 型糖尿病的急性缓解。随后的体重减轻会在数周到数月内逐渐增加，但会持续到长期。因此，人们非常希望以新型 2 型糖尿病和肥胖症联合药物的形式重现这些肠道激素变化。
