Genser Laurent, Soprani Antoine, Tabbara Malek, Siksik Jean-Michel, Cady Jean, Carandina Sergio
Assistance Publique-Hôpitaux de Paris (AP-HP), Department of Digestive and Hepato-Pancreato-Biliary Surgery, Liver Transplantation, Pitié-Salpêtrière University Hospital, Pierre & Marie Curie University, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Department of digestive surgery, Générale de Santé (GDS), Clinique Geoffroy-Saint Hilaire, 75005, Paris, France.
Langenbecks Arch Surg. 2017 Dec;402(8):1263-1270. doi: 10.1007/s00423-017-1615-4. Epub 2017 Aug 12.
Malnutrition after mini-gastric bypass (MGB) is a rare and dreaded complication with few data available regarding its surgical management. We aim to report the feasibility, safety, and results of laparoscopic reversal of MGB to normal anatomy (RMGB) in case of severe and refractory malnutrition syndrome after intensive nutritional support (SRMS).
A 10-year retrospective chart review was performed on patients who underwent RMGB (video included) for SRMS following MGB.
Twenty-six of 2934 patients underwent a RMGB at a mean delay of 20.9 ± 13.4 months post-MGB. At presentation, mean body mass index (BMI), excess weight loss (%EWL), and albumin serum level were 22 ± 4.4 kg/m, 103.6 ± 22.5%, and 25.5 ± 3.6 gr/L, respectively. Seventeen (63.5%) patients had at least one severe malnutrition related complication including severe edema in 13 (50%), venous ulcers in 2 (7.7%), infectious complications in 7 (27%), deep venous thrombosis in 5 (19.2%), and motor deficit in 5 (19.2%) patients. At surgical exploration, 8 of 12 (66.5%) patients had a biliary limb longer than 200 cm and 9 (34.6%) had bile reflux symptoms. Overall morbidity was 30.8% but lower when resecting the entire previous gastrojejunostomy with creation of a new jejunojejunostomy (8.3 vs 50%, p = 0.03). After a mean follow-up of 8 ± 9.7 months, all patients experienced a complete clinical and biological regression of the SRMS after the RMGB despite a mean 13.9 kg weight regain in 16 (61.5%) patients.
Post-MGB SRMS and its related comorbidities are rare but dreaded conditions. Although burdened by a significant postoperative morbidity and weight regain, RMGB remains an effective option to consider, when intensive nutritional support fails.
迷你胃旁路术(MGB)后发生的营养不良是一种罕见且可怕的并发症,关于其外科治疗的数据很少。我们旨在报告在强化营养支持后出现严重难治性营养不良综合征(SRMS)的情况下,腹腔镜下将MGB逆转至正常解剖结构(RMGB)的可行性、安全性及结果。
对接受MGB后因SRMS接受RMGB(包括视频资料)的患者进行了为期10年的回顾性病历审查。
2934例患者中有26例接受了RMGB,平均延迟时间为MGB术后20.9±13.4个月。就诊时,平均体重指数(BMI)、超重减轻百分比(%EWL)和血清白蛋白水平分别为22±4.4kg/m²、103.6±22.5%和25.5±3.6g/L。17例(63.5%)患者至少有一种与严重营养不良相关的并发症,包括13例(50%)严重水肿、2例(约7.7%)静脉溃疡、7例(27%)感染性并发症、5例(19.2%)深静脉血栓形成以及5例(19.2%)患者出现运动功能障碍。手术探查时,12例患者中有8例(66.5%)胆支长度超过200cm,9例(34.6%)有胆汁反流症状。总体发病率为30.8%,但在切除整个先前的胃空肠吻合口并创建新的空肠空肠吻合口时发病率较低(8.3%对~50%,p=0.03)。平均随访8±9.7个月后,尽管16例(61.5%)患者平均体重增加了13.9kg,但所有患者在RMGB术后SRMS均出现完全的临床和生物学缓解。
MGB术后SRMS及其相关合并症虽罕见但令人恐惧。尽管术后发病率和体重增加较为明显,但当强化营养支持失败时,RMGB仍是一个可考虑的有效选择。