Chen Xin-Rong, Ye L I, Fan Jun-Wen, Li Chang, Tang Fang, Liu Wei, Ren Lin-Zhu, Bai Jie-Ying
Jilin Provincial Key Laboratory of Animal Embryo Engineering,College of Animal Sciences,Jilin University,Changchun,P. R. China.
Laboratory Animal Center,Academy of Military Medical Sciences,Beijing,China.
Epidemiol Infect. 2017 Oct;145(13):2704-2710. doi: 10.1017/S0950268817001686. Epub 2017 Aug 14.
Babesiosis is an emerging tick-transmitted zoonosis prevalent in large parts of the world. This study was designed to determine the rates of Babesia microti infection among small rodents in Yunnan province, where human cases of babesiosis have been reported. Currently, distribution of Babesia in its endemic regions is largely unknown. In this study, we cataloged 1672 small wild rodents, comprising 4 orders, from nine areas in western Yunnan province between 2009 and 2011. Babesia microti DNA was detected by polymerase chain reaction in 4·3% (72/1672) of the rodents analyzed. The most frequently infected rodent species included Apodemus chevrieri and Niviventer fulvescens. Rodents from forests and shrublands had significantly higher Babesia infection rates. Genetic comparisons revealed that Babesia was most similar to the Kobe- and Otsu-type strains identified in Japan. A variety of rodent species might be involved in the enzootic maintenance and transmission of B. microti, supporting the need for further serological investigations in humans.
巴贝斯虫病是一种新出现的蜱传播人畜共患病，在世界大部分地区流行。本研究旨在确定云南省小型啮齿动物中巴贝斯微孢子虫的感染率，该省已报告有人感染巴贝斯虫病的病例。目前，巴贝斯虫在其流行地区的分布情况 largely unknown。在本研究中，我们在2009年至2011年期间对云南省西部九个地区的1672只小型野生啮齿动物进行了分类，这些啮齿动物分属4个目。通过聚合酶链反应在4.3%（72/1672）的分析啮齿动物中检测到了巴贝斯微孢子虫DNA。最常感染的啮齿动物物种包括高山姬鼠和黄胸鼠。来自森林和灌木丛的啮齿动物的巴贝斯虫感染率明显更高。基因比较显示，巴贝斯虫与在日本鉴定出的神户型和大津型菌株最为相似。多种啮齿动物物种可能参与了微小巴贝斯虫的自然疫源地维持和传播，这支持了对人类进行进一步血清学调查的必要性。
