Xu Chunsheng, Zhang Dongfeng, Tian Xiaocao, Duan Haiping, Wu Yili, Pang Zengchang, Li Shuxia, Tan Qihua
Department of Epidemiology and Health Statistics,School of Public Health,Qingdao University,Qingdao,Shandong,China.
Qingdao Municipal Center for Disease Control and Prevention,Qingdao,Shandong,China.
Twin Res Hum Genet. 2017 Oct;20(5):374-379. doi: 10.1017/thg.2017.42. Epub 2017 Aug 14.
The genetic and environmental impacts on correlations between hearing and cognitive functions have not been well studied. Cognitive function was evaluated by the Montreal Cognitive Assessment (MoCA). Hearing function was assessed by audiometric pure-tone hearing thresholds at different frequencies, including 0.5 kHz, 1 kHz, 2 kHz, 4 kHz, 8 kHz, and 12.5 kHz, with the lower hearing thresholds indicating better hearing function. Cognitive and hearing functions were measured on 379 complete twin pairs (240 monozygotic and 139 dizygotic pairs) with a median age of 50 years (range: 40-80 years). Bivariate twin models were fitted to quantify the genetic and environmental components of the correlations between hearing and cognitive functions. The analysis showed significantly high genetic correlation between 2 kHz of hearing and cognition (r G = -1.00, 95% CI [-1.00, -0.46]) and moderate genetic correlation between 4 kHz of hearing and cognition (r G = -0.62, 95% CI [-1.00, -0.14]). We found no significant genetic correlations between low as well as high frequencies of hearing and cognition. Low to moderate common and unique environmental correlations were shown between low frequencies of hearing and cognition (-0.13 to -0.39) and the common environmental correlation between 8 kHz, one of the high frequencies of hearing, and cognition (-0.22). The middle frequencies of hearing and cognitive functions may have a shared genetic basis. Low frequencies of hearing and cognition may share similar common and unique environmental factors. At 8 kHz, the high frequency of hearing and cognition may share similar common environment. This twin study detected a significant genetic and environmental basis in the phenotype correlation between cognition and hearing, which differed across frequencies.
基因和环境对听力与认知功能之间相关性的影响尚未得到充分研究。认知功能通过蒙特利尔认知评估量表（MoCA）进行评估。听力功能通过不同频率（包括0.5 kHz、1 kHz、2 kHz、4 kHz、8 kHz和12.5 kHz）的纯音听力阈值进行评估，听力阈值越低表明听力功能越好。对379对完整双胞胎（240对同卵双胞胎和139对异卵双胞胎）进行了认知和听力功能测量，双胞胎的年龄中位数为50岁（范围：40 - 80岁）。采用双变量双胞胎模型来量化听力与认知功能之间相关性的基因和环境成分。分析显示，2 kHz听力与认知之间存在显著的高基因相关性（r G = -1.00，95%置信区间[-1.00, -0.46]），4 kHz听力与认知之间存在中等基因相关性（r G = -0.62，95%置信区间[-1.00, -0.14]）。我们发现低频和高频听力与认知之间均无显著基因相关性。低频听力与认知之间显示出低到中等的共同和独特环境相关性（-0.13至-0.39），以及高频听力之一8 kHz与认知之间的共同环境相关性（-0.22）。听力和认知功能的中频可能具有共同的基因基础。低频听力和认知可能共享相似的共同和独特环境因素。在8 kHz时，高频听力和认知可能共享相似的共同环境。这项双胞胎研究在认知与听力的表型相关性中检测到了显著的基因和环境基础，且这种相关性在不同频率间存在差异。
