Pogrel M A, Ruggiero S L
Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, California, USA.
New York Center for Orthognathic and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery, Stony Brook School of Dental Medicine, New York, USA.
Int J Oral Maxillofac Surg. 2018 Feb;47(2):220-222. doi: 10.1016/j.ijom.2017.07.012. Epub 2017 Aug 10.
This article reports a type of localized osteonecrosis that can occur in patients who have had successful osseointegrated implants for many years and then commence anti-resorptive therapy. Eleven female patients were identified who had successful implant insertion, but who were placed on anti-resorptive therapy (bisphosphonates or denosumab) several years later and developed osteonecrosis around the implants. In each case, the osteonecrosis occurred only around the implants and not around the patient's remaining teeth. The implants of eight patients were removed with a sequestrum of bone tightly adherent to the implant. This is different from the normal pattern of implant failure. Implant failure can occur when patients with successfully integrated implants are later placed on anti-resorptive therapy, and the osteonecrosis takes a particular form where a sequestrum forms that remains adherent to the implant. Why the adjacent remaining teeth are not affected is unclear.
本文报道了一种局部性骨坏死，这种情况可能发生在已成功植入骨整合种植体多年，随后开始进行抗吸收治疗的患者身上。研究确定了11名女性患者，她们的种植体植入成功，但在几年后接受抗吸收治疗（双膦酸盐或地诺单抗）时，种植体周围出现了骨坏死。在每一个病例中，骨坏死仅发生在种植体周围，而不在患者的其余牙齿周围。8名患者的种植体被移除，有一块死骨紧紧附着在种植体上。这与种植体失败的正常模式不同。当成功植入种植体的患者后来接受抗吸收治疗时，可能会发生种植体失败，而骨坏死会呈现出一种特殊形式，即形成一块仍附着在种植体上的死骨。尚不清楚相邻的其余牙齿为何未受影响。
