Melissa Poh Su Wei, Phelim Yong Voon Chen, Navaratnam Visweswaran, Yoke Yin Chia
Division of Medicine, Pharmacy and Health Sciences, School of Biosciences, Taylor's University, Subang Jaya, Malaysia.
Research and Strategic Development, Taylor's University, Subang Jaya, Malaysia.
Biochem Insights. 2017 Jul 26;10:1178626417721676. doi: 10.1177/1178626417721676. eCollection 2017.
Based on a previous study, glabridin displayed a dose-dependent increase in estrogenic activity and cell proliferative activity in Ishikawa cells. However, when treated in combination with 17β-E, synergistic estrogenic effect was observed but without the same synergistic increase in cell proliferative effect. This study aimed to identify the estrogen and nonestrogen-regulated activities induced by glabridin and in combination with 17β-E in comparison with 17β-E. The results showed that 10 µM glabridin and the combination treatment of 100 nM glabridin with 1 nM 17β-E regulated both the genomic and nongenomic estrogen pathways to possibly provide benefits of estrogens in cardiovascular, circulatory, and vasculature systems. Meanwhile, the combination of 100 nM glabridin with 1 nM 17β-E seems to be more suitable to be used as an estrogen replacement. Finally, the results of this study have added on to the present knowledge of glabridin's function as a phytoestrogen and suggested new ideas for the usage of glabridin.
基于先前的一项研究，光甘草定在石川细胞中呈现出雌激素活性和细胞增殖活性的剂量依赖性增加。然而，当与17β - E联合处理时，观察到协同雌激素效应，但细胞增殖效应没有相同的协同增加。本研究旨在确定光甘草定以及与17β - E联合处理相对于17β - E所诱导的雌激素调节和非雌激素调节活性。结果表明，10 μM光甘草定以及100 nM光甘草定与1 nM 17β - E的联合处理均调节了基因组和非基因组雌激素途径，可能为心血管、循环和血管系统提供雌激素益处。同时，100 nM光甘草定与1 nM 17β - E的组合似乎更适合用作雌激素替代物。最后，本研究结果增加了对光甘草定作为植物雌激素功能的现有认识，并为光甘草定的使用提出了新的思路。
