轴向贝沙罗汀配体数量对奥沙利铂铂（IV）类似物细胞毒性的影响。

Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin.

作者信息

Nosova Yulia N, Zenin Ilia V, Maximova Varvara P, Zhidkova Ekaterina M, Kirsanov Kirill I, Lesovaya Ekaterina A, Lobas Anna A, Gorshkov Mikhail V, Kovaleva Olga N, Milaeva Elena R, Galanski Markus, Keppler Bernhard K, Nazarov Alexey A

机构信息

Department of Medicinal Chemistry and Fine Organic Synthesis, Lomonosov Moscow State University, Leninskie Gory 1/3, Moscow 119991, Russia.

Blokhin Cancer Research Center, 24 Kashirskoye Shosse, Moscow 115478, Russia.

出版信息

Bioinorg Chem Appl. 2017;2017:4736321. doi: 10.1155/2017/4736321. Epub 2017 Jul 19.

We present the synthesis and cytotoxic potencies of new Pt(IV) complexes with bexarotene, an anticancer drug that induces cell differentiation and apoptosis via selective activation of retinoid X receptors. In these complexes bexarotene is positioned as an axial ligand. The complex of one bexarotene ligand attached to Pt(IV) oxaliplatin moiety was potent whereas its counterpart carrying two bexarotene ligands was inactive.