Namikawa Tsutomu, Munekage Eri, Ogawa Maho, Oki Toyokazu, Munekage Masaya, Maeda Hiromichi, Kitagawa Hiroyuki, Sugimoto Takeki, Kobayashi Michiya, Hanazaki Kazuhiro
Department of Surgery, Kochi Medical School, Nankoku, Kochi 783-8505, Japan.
Cancer Treatment Center, Kochi Medical School, Nankoku, Kochi 783-8505, Japan.
Biomed Rep. 2017 Aug;7(2):159-162. doi: 10.3892/br.2017.943. Epub 2017 Jul 6.
The aim of the present study was to analyze the clinicopathologic features and treatment outcomes of gastric metastasis from other malignancies of solid organs. A review was conducted of patients with metastatic tumors in the stomach from other malignancies of solid organs detected endoscopically at the Department of Surgery, Kochi Medical School, from January 1991 to December 2015. Seven patients (four men and three women), with a median age of 64 years (range, 42-71 years), had metastatic gastric tumors. Median tumor size was 7.3 cm (range, 2.5-12.0 cm). The primary malignancy leading to metastatic tumors in the stomach was esophageal cancer in three patients, breast cancer in two patients, renal cell carcinoma in one patient, and ovarian cancer in one patient. Gastric metastasis presented as solitary lesions in six patients and as multiple lesions in one patient. Four patients had solitary gastric metastasis, whereas three had multiple metastases in other organs. The median tumor size was significantly smaller in patients with solitary rather than multiple metastases (4.6 vs. 12.0 cm, respectively; P=0.038). Three patients received systemic therapy and four underwent surgical resection of the metastatic tumor, and of these, only one was alive 58 months after surgery. Clinicians should be aware of the possible existence of metastatic gastric cancer, especially in breast carcinoma and esophageal cancer. Surgical resection may considerably improve patients' quality of life, and could be of benefit when there is a risk of bleeding and/or a solitary metastasis.
本研究旨在分析其他实体器官恶性肿瘤胃转移的临床病理特征及治疗结果。对1991年1月至2015年12月在高知医科大学外科经内镜检查发现的其他实体器官恶性肿瘤胃转移患者进行了回顾性研究。7例患者（4例男性和3例女性）发生胃转移瘤，中位年龄64岁（范围42 - 71岁）。肿瘤中位大小为7.3 cm（范围2.5 - 12.0 cm）。导致胃转移瘤的原发恶性肿瘤中，3例为食管癌，2例为乳腺癌，1例为肾细胞癌，1例为卵巢癌。6例患者胃转移表现为孤立性病变，1例为多发性病变。4例患者为孤立性胃转移，3例在其他器官有多发转移。孤立性转移患者的肿瘤中位大小显著小于多发转移患者（分别为4.6 cm和12.0 cm；P = 0.038）。3例患者接受了全身治疗，4例接受了转移瘤手术切除，其中仅1例术后58个月仍存活。临床医生应意识到转移性胃癌的可能存在，尤其是在乳腺癌和食管癌患者中。手术切除可显著改善患者生活质量，在有出血风险和/或孤立性转移时可能有益。
