胆汁酸引发胆汁淤积性肝损伤中肝脏炎症的机制研究。
Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury.
作者信息
Cai Shi-Ying, Boyer James L
机构信息
Department of Internal Medicine and Liver Center, Yale University School of Medicine, New Haven, CT 06520, USA.
出版信息
Inflamm Cell Signal. 2017;4(2). Epub 2017 Jun 19.
Abstract
The mechanism of bile acid induced cholestatic liver injury remains controversial, thus hindering the development of new therapies for these diseases. In this research highlight, we briefly review the evolution of our understanding of the pathogenesis of bile acid induced liver injury, and summarize our recent findings on this topic. Our data suggests that under pathophysiological conditions bile acid induced liver injury is mediated by inflammatory responses that are initiated from stressed hepatocytes. We conclude by mentioning potential new therapeutic approaches for treating cholestatic liver injury based on these pathophysiologic concepts.
摘要
胆汁酸诱导的胆汁淤积性肝损伤机制仍存在争议，这阻碍了针对这些疾病的新疗法的开发。在本研究亮点中，我们简要回顾了我们对胆汁酸诱导肝损伤发病机制认识的演变，并总结了我们最近在该主题上的发现。我们的数据表明，在病理生理条件下，胆汁酸诱导的肝损伤是由应激肝细胞引发的炎症反应介导的。我们基于这些病理生理概念提及治疗胆汁淤积性肝损伤的潜在新治疗方法来结束本文。
相似文献
1
Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury.
Inflamm Cell Signal. 2017;4(2). Epub 2017 Jun 19.
2
The role of bile acids in cholestatic liver injury.
Ann Transl Med. 2021 Apr;9(8):737. doi: 10.21037/atm-20-5110.
3
Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response.
JCI Insight. 2017 Mar 9;2(5):e90780. doi: 10.1172/jci.insight.90780.
4
The Role of Inflammation in the Mechanisms of Bile Acid-Induced Liver Damage.
Dig Dis. 2017;35(3):232-234. doi: 10.1159/000450916. Epub 2017 Mar 1.
5
Mechanisms of bile acid mediated inflammation in the liver.
Mol Aspects Med. 2017 Aug;56:45-53. doi: 10.1016/j.mam.2017.06.001. Epub 2017 Jul 1.
6
Loss of cellular FLICE-inhibitory protein promotes acute cholestatic liver injury and inflammation from bile duct ligation.
Am J Physiol Gastrointest Liver Physiol. 2018 Mar 1;314(3):G319-G333. doi: 10.1152/ajpgi.00097.2017. Epub 2017 Nov 30.
7
Sweroside ameliorates α-naphthylisothiocyanate-induced cholestatic liver injury in mice by regulating bile acids and suppressing pro-inflammatory responses.
Acta Pharmacol Sin. 2016 Sep;37(9):1218-28. doi: 10.1038/aps.2016.86. Epub 2016 Aug 8.
8
Cenicriviroc, a cytokine receptor antagonist, potentiates all-trans retinoic acid in reducing liver injury in cholestatic rodents.
Liver Int. 2018 Jun;38(6):1128-1138. doi: 10.1111/liv.13698. Epub 2018 Feb 13.
9
Bile acid homeostasis paradigm and its connotation with cholestatic liver diseases.
Drug Discov Today. 2019 Jan;24(1):112-128. doi: 10.1016/j.drudis.2018.09.007. Epub 2018 Sep 20.
10
Early indications of ANIT-induced cholestatic liver injury: Alteration of hepatocyte polarization and bile acid homeostasis.
Food Chem Toxicol. 2017 Dec;110:1-12. doi: 10.1016/j.fct.2017.09.051. Epub 2017 Oct 3.
引用本文的文献
1
Human Hepatocellular response in Cholestatic Liver Diseases.
Organogenesis. 2023 Dec 31;19(1):2247576. doi: 10.1080/15476278.2023.2247576.
2
L. and the Underlying Molecular Mechanisms for Its Choleretic, Cholagogue, and Regenerative Properties.
Pharmaceuticals (Basel). 2023 Jun 15;16(6):887. doi: 10.3390/ph16060887.
3
Applying Lipidomics to Non-Alcoholic Fatty Liver Disease: A Clinical Perspective.
Nutrients. 2023 Apr 20;15(8):1992. doi: 10.3390/nu15081992.
4
Leptin Influence Cholelithiasis Formation by Regulating Bile Acid Metabolism.
Turk J Gastroenterol. 2021 Jan;32(1):97-105. doi: 10.5152/tjg.2020.19594.
5
Hepatic interferon γ and tumor necrosis factor a expression in infants with neonatal cholestasis and cytomegalovirus infection.
Clin Exp Hepatol. 2020 Dec;6(4):367-373. doi: 10.5114/ceh.2020.102172. Epub 2020 Dec 30.
6
Roles of the inflammasome in the gut‑liver axis (Review).
Mol Med Rep. 2019 Jan;19(1):3-14. doi: 10.3892/mmr.2018.9679. Epub 2018 Nov 20.
7
Gulf war illness-related chemicals increase CD11b/c monocyte infiltration into the liver and aggravate hepatic cholestasis in a rodent model.
Sci Rep. 2018 Sep 3;8(1):13147. doi: 10.1038/s41598-018-31599-9.
本文引用的文献
1
Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response.
JCI Insight. 2017 Mar 9;2(5):e90780. doi: 10.1172/jci.insight.90780.
2
The Role of Inflammation in the Mechanisms of Bile Acid-Induced Liver Damage.
Dig Dis. 2017;35(3):232-234. doi: 10.1159/000450916. Epub 2017 Mar 1.
3
Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice.
Hepatology. 2015 Jul;62(1):207-19. doi: 10.1002/hep.27694. Epub 2015 May 8.
4
Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype.
Hepatology. 2015 Jan;61(1):260-7. doi: 10.1002/hep.27240. Epub 2014 Aug 25.
5
Altered expression and function of canalicular transporters during early development of cholestatic liver injury in Abcb4-deficient mice.
Am J Physiol Gastrointest Liver Physiol. 2014 Apr 15;306(8):G670-6. doi: 10.1152/ajpgi.00334.2013. Epub 2014 Jan 30.
6
Plasma biomarkers of liver injury and inflammation demonstrate a lack of apoptosis during obstructive cholestasis in mice.
Toxicol Appl Pharmacol. 2013 Dec 15;273(3):524-31. doi: 10.1016/j.taap.2013.09.023. Epub 2013 Oct 3.
7
Novel insight into mechanisms of cholestatic liver injury.
World J Gastroenterol. 2012 Sep 28;18(36):4985-93. doi: 10.3748/wjg.v18.i36.4985.
8
Effect of bile duct ligation on bile acid composition in mouse serum and liver.
Liver Int. 2012 Jan;32(1):58-69. doi: 10.1111/j.1478-3231.2011.02662.x. Epub 2011 Oct 17.
9
Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis.
Am J Pathol. 2011 Jan;178(1):175-86. doi: 10.1016/j.ajpath.2010.11.026. Epub 2010 Dec 23.
10
Hepatocyte death: a clear and present danger.
Physiol Rev. 2010 Jul;90(3):1165-94. doi: 10.1152/physrev.00061.2009.
Zotero 插件