胆汁酸引发胆汁淤积性肝损伤中肝脏炎症的机制研究。
Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury.
作者信息
Cai Shi-Ying, Boyer James L
机构信息
Department of Internal Medicine and Liver Center, Yale University School of Medicine, New Haven, CT 06520, USA.
出版信息
Inflamm Cell Signal. 2017;4(2). Epub 2017 Jun 19.
Abstract
The mechanism of bile acid induced cholestatic liver injury remains controversial, thus hindering the development of new therapies for these diseases. In this research highlight, we briefly review the evolution of our understanding of the pathogenesis of bile acid induced liver injury, and summarize our recent findings on this topic. Our data suggests that under pathophysiological conditions bile acid induced liver injury is mediated by inflammatory responses that are initiated from stressed hepatocytes. We conclude by mentioning potential new therapeutic approaches for treating cholestatic liver injury based on these pathophysiologic concepts.
摘要
胆汁酸诱导的胆汁淤积性肝损伤机制仍存在争议，这阻碍了针对这些疾病的新疗法的开发。在本研究亮点中，我们简要回顾了我们对胆汁酸诱导肝损伤发病机制认识的演变，并总结了我们最近在该主题上的发现。我们的数据表明，在病理生理条件下，胆汁酸诱导的肝损伤是由应激肝细胞引发的炎症反应介导的。我们基于这些病理生理概念提及治疗胆汁淤积性肝损伤的潜在新治疗方法来结束本文。
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