Liver Unit, Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London W21NY, UK.
Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London W21NY, UK.
Nutrients. 2023 Apr 20;15(8):1992. doi: 10.3390/nu15081992.
The prevalence of Non-alcoholic fatty liver disease (NAFLD) and associated complications, such as hepatocellular carcinoma (HCC), is growing worldwide, due to the epidemics of metabolic risk factors, such as obesity and type II diabetes. Among other factors, an aberrant lipid metabolism represents a crucial step in the pathogenesis of NAFLD and the development of HCC in this population. In this review, we summarize the evidence supporting the application of translational lipidomics in NAFLD patients and NAFLD associated HCC in clinical practice.
非酒精性脂肪性肝病（NAFLD）及其相关并发症（如肝细胞癌 [HCC]）的患病率在全球范围内呈上升趋势，这是由于代谢危险因素（如肥胖和 2 型糖尿病）的流行。在其他因素中，异常的脂质代谢代表了 NAFLD 发病机制和该人群 HCC 发展的关键步骤。在这篇综述中，我们总结了支持在 NAFLD 患者和 NAFLD 相关 HCC 中应用转化脂质组学的证据。
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