筛查频率和组织学类型影响宫颈癌筛查效果：一项全国性队列研究。

Screening frequency and histologic type influence the efficacy of cervical cancer screening: A nationwide cohort study.

作者信息

Chiang Ying-Cheng, Chen Yun-Yuan, Hsieh Shu-Feng, Chiang Chun-Ju, You San-Lin, Cheng Wen-Fang, Lai Mei-Shu, Chen Chi-An

机构信息

Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan.

Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Research, Taiwan Blood Services Foundation, Taipei, Taiwan.

出版信息

Taiwan J Obstet Gynecol. 2017 Aug;56(4):442-448. doi: 10.1016/j.tjog.2017.01.010.

DOI:10.1016/j.tjog.2017.01.010

PMID:28805598

Abstract

OBJECTIVE

To evaluate the influence of age, screening interval, and histologic type on the effect of Pap smears in cervical cancer screening.

MATERIALS AND METHODS

Data were retrieved from the Taiwan National Cancer Registry and Cervical Cancer Screening Registration System for the period from 2002 to 2010. Age, Pap smear interval, FIGO stage, and histology were further analyzed.

RESULTS

A total of 12,294 women with cervical cancer were enrolled, including 10,040 with squamous cell carcinoma (SCC), 1720 with adenocarcinoma (ADC), 401 with adenosquamous carcinoma (ASC), and 133 with small cell neuroendocrine carcinoma (SMC). Women who had a Pap smear at an interval of <3 years had a significantly higher proportion of stage I disease than women who had never undergone cervical cancer screening (p < 0.0001). Greater than 40% of women with SCCs in each age group had never had a Pap smear; however, women with ADCs were predominantly in the younger age and greater than 40% of women with ADCs had Pap smear at intervals < 3 years.

CONCLUSIONS

Pap smear is more effective in screening for cervical SCCs compared to cervical ADCs. Improving adherence to screening recommendations is important for the prevention of cervical SCC, especially in elderly women.

摘要

目的

评估年龄、筛查间隔和组织学类型对子宫颈癌筛查中宫颈涂片检查效果的影响。

材料与方法

数据取自2002年至2010年台湾地区国家癌症登记处和子宫颈癌筛查登记系统。对年龄、宫颈涂片检查间隔、国际妇产科联盟（FIGO）分期和组织学进行进一步分析。

结果

共纳入12294例子宫颈癌女性患者，其中10040例为鳞状细胞癌（SCC），1720例为腺癌（ADC），401例为腺鳞癌（ASC），133例为小细胞神经内分泌癌（SMC）。宫颈涂片检查间隔<3年的女性中，I期疾病的比例显著高于从未接受过子宫颈癌筛查的女性（p<0.0001）。各年龄组中，超过40%的SCC女性从未进行过宫颈涂片检查；然而，ADC女性主要为年轻女性，超过40%的ADC女性宫颈涂片检查间隔<3年。