Department of Obstetrics and Gynecology, University of Virginia, Charlottesville, VA, United States.
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO, United States; Section of Palliative Care, Division of General of Internal Medicine, University of Colorado School of Medicine, Aurora, CO, United States.
Gynecol Oncol. 2017 Nov;147(2):456-459. doi: 10.1016/j.ygyno.2017.08.008. Epub 2017 Aug 12.
To characterize risk for opioid misuse among gynecologic oncology patients.
The Opioid Risk Tool (ORT), a validated screen for opioid misuse risk, was administered to a convenience sample of patients with gynecologic cancer receiving opioid prescriptions in gynecologic oncology or palliative care clinics from January 2012-June 2016. Demographic and clinical information was abstracted on chart review. The primary outcome was ORT risk level (low vs. moderate or high). Chi-square tests were performed for categorical variables.
A total of 118 women were screened. Most women were Caucasian (79%) with a median age of 57years. Ovarian cancer patients comprised 46% of the cohort with fewer endometrial (25%), cervical (23%), vulvar (4%), and vaginal (2%) cancer patients. The median ORT score was 1.0 (range, 0-10) out of a possible 26. Overall, 87% of patients were categorized as low-risk for opioid misuse, 7% as moderate-risk, and 6% as high-risk. Patients who were at moderate or high-risk of opioid misuse were significantly younger (47 vs. 58years, p=0.02), more likely to have cervical cancer (p=0.02), be smokers (p=0.01) and be uninsured or on Medicare (p=0.03).
Most gynecologic oncology patients in our cohort were low-risk for opioid misuse (87%). Cervical cancer patients were more likely to be moderate to high-risk for misuse. Future screening efforts for opioid misuse may have the highest utility in this subset of patients.
描述妇科肿瘤患者阿片类药物滥用的风险特征。
采用经过验证的阿片类药物滥用风险筛查工具(ORT),对 2012 年 1 月至 2016 年 6 月在妇科肿瘤或姑息治疗诊所接受阿片类药物处方的妇科癌症患者进行了便利抽样。通过病历回顾提取人口统计学和临床信息。主要结局是 ORT 风险水平(低 vs. 中或高)。对于分类变量,进行了卡方检验。
共筛查了 118 名女性。大多数女性为白人(79%),中位年龄为 57 岁。卵巢癌患者占队列的 46%,子宫内膜癌(25%)、宫颈癌(23%)、外阴癌(4%)和阴道癌(2%)患者较少。ORT 评分中位数为 1.0(范围 0-10),满分为 26 分。总体而言,87%的患者被归类为阿片类药物滥用低风险,7%为中风险,6%为高风险。中或高风险阿片类药物滥用的患者明显更年轻(47 岁 vs. 58 岁,p=0.02),更可能患有宫颈癌(p=0.02),是吸烟者(p=0.01),并且没有保险或参加医疗保险(p=0.03)。
我们队列中的大多数妇科肿瘤患者阿片类药物滥用风险较低(87%)。宫颈癌患者更有可能处于中至高风险滥用。未来针对阿片类药物滥用的筛查工作可能对这部分患者最有用。