Chen H C, Hsieh M T, Shibuya T K
Int J Clin Pharmacol Ther Toxicol. 1986 Dec;24(12):646-50.
The ancient Chinese remedy Suanzaorentang was originally described in Kin-Kue-Yao-Lueh for patients with weakness, irritability and insomnia. In our preliminary observations on suanzaorentang, it seemed to be a promising anxiolytic remedy. A controlled comparative double-blind clinical trial was set up to assess the anxiolytic effect of suanzaorentang. Suanzaorentang (250 mg t.i.d.) and diazepam (2 mg t.i.d.) had almost the same anxiolytic effect. However, suanzaorentang, but not diazepam, improved the psychomotor performance during the daytime. No significant subjective side effects were observed during treatment with suanzaorentang. All laboratory tests, including liver function tests (serum SGOT, SGPT, albumin, globulin, bilirubin), renal function tests (BUN, serum creatinine), electrolyte balances (serum K+, Na+, Cl-, Ca++), serum cholesterol-triglyceride-HDL-c, thyroid function test (serum T4), chest P-A X-ray film, blood-urine-stool routine examinations (BUS routines), were unaltered after one week's administration of the compound.
中国古代方剂酸枣仁汤最初记载于《金匮要略》，用于治疗体虚、易怒和失眠的患者。在我们对酸枣仁汤的初步观察中，它似乎是一种很有前景的抗焦虑方剂。为此开展了一项对照比较双盲临床试验，以评估酸枣仁汤的抗焦虑效果。酸枣仁汤（250毫克，每日三次）和地西泮（2毫克，每日三次）具有几乎相同的抗焦虑效果。然而，酸枣仁汤而非地西泮改善了白天的精神运动表现。在服用酸枣仁汤治疗期间未观察到明显的主观副作用。在给予该复方制剂一周后，所有实验室检查，包括肝功能检查（血清谷草转氨酶、谷丙转氨酶、白蛋白、球蛋白、胆红素）、肾功能检查（血尿素氮、血清肌酐）、电解质平衡（血清钾离子、钠离子、氯离子、钙离子）、血清胆固醇-甘油三酯-高密度脂蛋白胆固醇、甲状腺功能检查（血清甲状腺素）、胸部正位X线片、血尿便常规检查，均未发生改变。
