Diaz Raul E, Bertocchini Federica, Trainor Paul A
Department of Biology, La Sierra University, Riverside, CA, 92515, USA.
Natural History Museum of Los Angeles County, Los Angeles, CA, 90007, USA.
Methods Mol Biol. 2017;1650:269-284. doi: 10.1007/978-1-4939-7216-6_18.
Living amniotes comprise three major phylogenetic lineages: mammals, birds, and non-avian reptiles. Mouse and avian embryos continue to be the primary species used in experimental settings to further our knowledge and understanding of the genetics and embryology of amniotes. In comparison, non-avian reptiles, which constitute up to 40% of all living amniotes, have played a comparatively minor role. Studies of non-avian reptiles are, however, paramount for providing insights into the evolutionary changes that occurred in the transition from reptilian-like amniote ancestors to derived mammalian and avian species. Here, we introduce the Veiled Chameleon, a squamate reptile, as a new experimental model for examining fundamental questions in development, evolution, and disease.
哺乳动物、鸟类和非鸟类爬行动物。小鼠和鸟类胚胎仍然是实验中用于增进我们对羊膜动物遗传学和胚胎学认识与理解的主要物种。相比之下，占现存所有羊膜动物多达40%的非鸟类爬行动物所起的作用相对较小。然而，对非鸟类爬行动物的研究对于深入了解从类似爬行动物的羊膜动物祖先向衍生的哺乳动物和鸟类物种过渡过程中发生的进化变化至关重要。在此，我们引入了一种有鳞目爬行动物——也门变色龙，作为研究发育、进化和疾病基本问题的新实验模型。
