Prinsen J H, Günther H, Breuer J
J Clin Chem Clin Biochem. 1986 Dec;24(12):1001-7.
The catalytic activity of lactate dehydrogenase, gamma-glutamyltransferase, alkaline phosphatase, alanine aminopeptidase and N-acetyl-beta-D-glucosaminidase has been measured in 24 h urines of patients with a calcium oxalate calculus (9 men, 11 women) and has been compared with those of a reference collective (11 men, 10 women). The diagnostic sensitivity and the diagnostic specificity have been calculated according to four different discrimination methods in which the diagnostic sensitivity lies between 65% and 100%, the diagnostic specificity between 72% and 100%. Within the reference group there was a correlation between the excretion of the three brush-border enzymes, whereas within the group of patients only a correlation between gamma-glutamyltransferase and N-acetyl-beta-D-glucosaminidase was observed. From this pathophysiological conclusions can be drawn.
已对草酸钙结石患者（9名男性，11名女性）的24小时尿液中的乳酸脱氢酶、γ-谷氨酰转移酶、碱性磷酸酶、丙氨酸氨基肽酶和N-乙酰-β-D-氨基葡萄糖苷酶的催化活性进行了测定，并与一个参考群体（11名男性，10名女性）的相应指标进行了比较。根据四种不同的判别方法计算了诊断敏感性和诊断特异性，其中诊断敏感性在65%至100%之间，诊断特异性在72%至100%之间。在参考组中，三种刷状缘酶的排泄之间存在相关性，而在患者组中，仅观察到γ-谷氨酰转移酶和N-乙酰-β-D-氨基葡萄糖苷酶之间存在相关性。由此可得出病理生理学结论。
