Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ, UK.
Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12687-12691. doi: 10.1002/anie.201706378. Epub 2017 Aug 30.
Through serendipitous discovery, a palladium bis(phosphine) complex was identified as a catalyst for the selective transformation of sp C-F and sp C-H bonds of fluoroarenes and heteroarenes to sp C-Al bonds (19 examples, 1 mol % Pd loading). The carbon-fluorine bond functionalization reaction is highly selective for the formation of organoaluminium products in preference to hydrodefluorination products (selectivity=4.4:1 to 27:1). Evidence is presented for a tandem catalytic process in which hydrodefluorination is followed by sp C-H alumination.
通过偶然发现，一种钯双（膦）配合物被鉴定为一种催化剂，可选择性地将氟芳烃和杂芳烃中的 sp C-F 和 sp C-H 键转化为 sp C-Al 键（19 个实例，1 mol% Pd 负载量）。碳-氟键官能化反应高度选择性地生成有机铝产物，而不是氢解氟化物产物（选择性=4.4:1 至 27:1）。提出了一个串联催化过程的证据，其中包括氢解氟化物和 sp C-H 铝化反应。
