Dong Xinmei, Kiss Lóránd, Petrikovics Ilona, Thompson David E
Department of Chemistry, Sam Houston State University , Huntsville, Texas 77341, United States.
Chem Res Toxicol. 2017 Sep 18;30(9):1661-1663. doi: 10.1021/acs.chemrestox.7b00181. Epub 2017 Aug 18.
Dimethyl trisulfide (DMTS) is a promising antidotal candidate for cyanide intoxication. DMTS acts as a sulfur donor in the conversion of cyanide to the less-toxic thiocyanate. The alternate reaction pathways of DMTS in the blood are not well understood. We report changes in the hemoglobin absorption spectrum upon reaction with DMTS. These changes closely match those induced by the known methemoglobin former, sodium nitrite. The kinetics of methemoglobin formation with DMTS is slower than with sodium nitrite. These results support the hypothesis that a potentially significant side-reaction of the therapeutically administered DMTS is the oxidization of hemoglobin to methemoglobin.
二甲基三硫醚（DMTS）是一种有前景的氰化物中毒解毒候选物。DMTS在氰化物转化为毒性较小的硫氰酸盐的过程中作为硫供体。DMTS在血液中的替代反应途径尚未完全了解。我们报告了与DMTS反应后血红蛋白吸收光谱的变化。这些变化与已知的高铁血红蛋白形成剂亚硝酸钠引起的变化密切匹配。DMTS形成高铁血红蛋白的动力学比亚硝酸钠慢。这些结果支持了以下假设：治疗性施用的DMTS的潜在重大副反应是血红蛋白氧化为高铁血红蛋白。
