Yoshida J, Tokumura A, Fukuzawa K, Terao M, Takauchi K, Tsukatani H
J Pharm Pharmacol. 1986 Dec;38(12):878-82. doi: 10.1111/j.2042-7158.1986.tb03375.x.
A phospholipid that differs from known active lipids and causes potent platelet aggregation and weak hypotension has been isolated from bovine brain. Its platelet aggregating effect on heparinized platelet-rich plasma from rabbits, was at a threshold concentration of about 0.2 nmol ml-1 as phosphorus. The effect was inhibited by CV-3988. The phospholipid was converted by diazomethane treatment to another active lipid that caused short-term hypotension, but not platelet aggregation, rather it inhibited the aggregation of rabbit heparinized platelets induced by platelet-activating factor.
从牛脑中分离出一种与已知活性脂质不同的磷脂，它能引起强烈的血小板聚集并导致轻度低血压。它对兔肝素化富血小板血浆的血小板聚集作用，以磷计的阈值浓度约为0.2 nmol/ml。该作用可被CV - 3988抑制。经重氮甲烷处理后，这种磷脂转变为另一种活性脂质，后者引起短期低血压，但不引起血小板聚集，反而抑制血小板活化因子诱导的兔肝素化血小板聚集。
