N-甲酰青霉胺和青霉胺作为青霉素在溶液中的降解产物。

N-formylpenicillamine and penicillamine as degradation products of penicillins in solution.

作者信息

Bird A E, Jennings K R, Marshall A C

出版信息

J Pharm Pharmacol. 1986 Dec;38(12):913-6. doi: 10.1111/j.2042-7158.1986.tb03382.x.

DOI:10.1111/j.2042-7158.1986.tb03382.x

Abstract

The degradation of several penicillins in unbuffered aqueous solution produces N-formylpenicillamine, in some cases in high yield. Very little or no penicillamine is formed under these conditions. N-Formylpenicillamine was produced from benzylpenicillin at pH values between 2.5 and 7, with a maximum yield of 30% at pH 5, whereas penicillamine was produced only at pH 5 or below in a yield of less than 1%. Benzylpenicillenic acid at pH 5 gave a 20% yield of N-formylpenicillamine and no penicillamine whereas benzylpenicilloic, penilloic and penillic acids gave no N-formylpenicillamine and a small amount of penicillamine.

摘要

几种青霉素在无缓冲水溶液中的降解会产生N-甲酰青霉胺，在某些情况下产率很高。在这些条件下，很少或几乎不形成青霉胺。在pH值为2.5至7的条件下，苄青霉素可产生N-甲酰青霉胺，在pH 5时产率最高可达30%，而青霉胺仅在pH 5或更低时产生，产率低于1%。pH 5时的苄青霉素烯酸产生20%的N-甲酰青霉胺，不产生青霉胺，而苄青霉素酸、青霉二酸和青霉三酸不产生N-甲酰青霉胺，只产生少量青霉胺。