Fung Y K, Lau Y S
J Pharm Pharmacol. 1986 Dec;38(12):920-2. doi: 10.1111/j.2042-7158.1986.tb03384.x.
The acute effects of nicotine (1.5 mg kg-1 day-1) on the striatal dopaminergic system have been examined in the rat. Twenty-four hours after nicotine treatment, spontaneous locomotor activity in response to apomorphine or (+)-amphetamine and the binding of [3H]spiperone to striatal particulates were determined. Pretreatment of nicotine did not alter the characteristics of [3H]spiperone binding to striatal dopamine receptors. The nicotine treatment did not affect the apomorphine-induced locomotor activity, however, the (+)-amphetamine-stimulated locomotor activity was attenuated. These results suggest that nicotine acutely alters the presynaptic dopaminergic activity without significantly affecting the postsynaptic dopaminergic function.
已在大鼠中研究了尼古丁（1.5毫克/千克/天）对纹状体多巴胺能系统的急性影响。尼古丁处理24小时后，测定了对阿扑吗啡或（+）-苯丙胺的自发运动活性以及[3H]司哌罗宁与纹状体微粒的结合。尼古丁预处理未改变[3H]司哌罗宁与纹状体多巴胺受体结合的特性。尼古丁处理不影响阿扑吗啡诱导的运动活性，然而，（+）-苯丙胺刺激的运动活性减弱。这些结果表明，尼古丁急性改变突触前多巴胺能活性，而对突触后多巴胺能功能无显著影响。
